{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:46:22Z","timestamp":1783550782395,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hemodialysis requires reliable vascular access, and arteriovenous fistulas (AVF) are preferred for their superior patency and fewer complications. However, AVF failure remains high, with 50% becoming nonfunctional within 2\u2009years. Inflammatory biomarkers can contribute to AVF failure, yet the specific biomarkers involved remain to be identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>We aim to determine the prognostic significance of inflammatory biomarkers in predicting primary AVF failure in hemodialysis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The electronic search was performed in different databases: PubMed, Embase, and Cochrane Library, from inception to June 2024. Statistical analysis was performed using R software 4.3.1. A random-effects model was employed to compute mean differences (MD) and risk ratios (RR) with 95% confidence intervals (CI) for continuous and binary endpoints. The results were reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement guideline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 15 studies, encompassing 1809 patients with a mean age of 62\u2009years, were included. Over follow-up ranging from 6\u2009weeks to 26\u2009months, we did not observe a significant difference in the levels of monocyte chemotactic protein 1 (MCP-1; 12.15\u2009pg\/mL; 95% CI \u221214.26 to 38.56;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.37), tumor necrosis factor alpha (TNF-\u03b1; 0.90\u2009pg\/mL; 95% CI \u221238.77 to 40.57;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.96) and white blood cells (WBC; 0.31\u2009g\/L; 95% CI \u22120.05 to 0.66;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.09) between the group experiencing AVF maturation and those facing AVF failure. However, there was a significant elevation in C-reactive protein (CRP) levels in the AVF failure group (2.89\u2009mg\/L; 95% CI 0.31\u20135.47;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Despite the increased CRP values within the AVF failure cohort and the significance noted in individual studies, our investigation did not find discernible effects attributable to other inflammatory and fibrotic biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298251345510","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T07:49:08Z","timestamp":1748591348000},"page":"495-504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The predictive value of inflammatory biomarkers for arteriovenous fistula failure: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-5060","authenticated-orcid":false,"given":"Mar\u00edlia Oberto da Silva","family":"Gobbo","sequence":"first","affiliation":[{"name":"Department of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre - RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanize Louize","family":"Milbradt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Santa Maria, Santa Maria - RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Yamada","family":"Fujimura J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculdade de Medicina de Mar\u00edlia, Mar\u00edlia - SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan Yuji","family":"Ura Sudo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Grande Dourados, Dourados - MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6842-354X","authenticated-orcid":false,"given":"Mariane Amado","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre - RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarbas Rodrigues","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre - RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Poli-de-Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre - RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-jbn-2021-0198"},{"issue":"1","key":"e_1_3_2_3_2","volume":"37","author":"III. 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