{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:07:58Z","timestamp":1790622478669,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Short peripheral catheters (SPC) are commonly used in hospitalized patients to provide vascular access for short-term intravenous therapies. However, complications such as infection, thrombophlebitis, and fibroblastic sleeve formation can lead to premature catheter failure, negatively impacting patient care and increasing healthcare costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aims to identify risk factors associated with fibroblastic sleeve formation and evaluate their role in SPC failure, thereby supporting improved risk stratification and catheter management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a secondary analysis of a prospective observational study involving 200 devices, monitored daily with ultrasound to detect complications, including fibroblastic sleeves. Patient-related and therapy-related risk factors were analyzed using univariate and multivariate Cox models to identify predictors of fibroblastic sleeve formation and device failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 200 catheters, 94 (47%) developed fibroblastic sleeves detectable by ultrasound. In multivariate analysis, antibiotic therapy requiring central venous access was the only independent predictor of its formation (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03; HR, 2.09; 95% CI, 1.08\u20134.03). Risk factors independently associated with failure included older age, diabetes, cancer, bedridden status, use of antibiotics requiring central access, and omeprazole infusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Antibiotic infusion through short peripheral catheters was identified as a key risk factor for fibroblastic sleeve formation, while patient-related factors and specific therapies were associated with catheter failure. These findings underscore the importance of selecting and monitoring devices carefully in high-risk patients to minimize complications and enhance vascular access outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298251395371","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T04:50:33Z","timestamp":1765169433000},"page":"1229-1233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Fibroblastic sleeve and short peripheral catheter failures: Impact of risk factors"],"prefix":"10.1177","volume":"27","author":[{"given":"Alessia","family":"Meschia","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-1822","authenticated-orcid":false,"given":"Davide","family":"Giustivi","sequence":"additional","affiliation":[{"name":"Post Anesthesia Care Unit, Vascular Access Team ASST Lodi, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita","family":"Celano","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Cattalani","sequence":"additional","affiliation":[{"name":"University of Milan, ASST Fatebenefratelli Sacco Section, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Camilli","sequence":"additional","affiliation":[{"name":"Auxologico San Luca, Reparto Cardiologico acuti Riabilitazione, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Bartoli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Urso","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Calloni","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Cirigliano","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Taino","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cogliati","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-1091","authenticated-orcid":false,"given":"Antonio","family":"Gidaro","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Luigi Sacco Hospital, Milan, 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