{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:07:04Z","timestamp":1784531224389,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Cooperatio Program, research area Medical Diagnostics and Basic Medical Sciences"},{"DOI":"10.13039\/501100003243","name":"ministerstvo zdravotnictv\u00ed cesk\u00e9 republikys","doi-asserted-by":"publisher","award":["00669806"],"award-info":[{"award-number":["00669806"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vascular access devices (VADs) are increasingly used for blood sampling, yet optimal discard volumes remain uncertain, particularly when EDTA-based lock solutions are used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate whether discarding 1 mL is sufficient for reliable laboratory testing after use of 4% tetrasodium EDTA catheter lock solution (Kitelock\u2122) in PICC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a prospective study, 10 patients with single-lumen peripherally inserted central catheters (polyurethane, 4F, open-ended) underwent blood sampling after flushing the catheter and discarding 1\u2009mL, corresponding to approximately two dead spaces for the shortened catheters used. Five consecutive tubes were analyzed per sample type (biochemistry, hematology, coagulation). Agreement with the reference tube (tube 5) was assessed using Bland\u2013Altman plots, clinically acceptable intervals (CAI), intraclass correlation coefficient (ICC), and Lin\u2019s concordance correlation coefficient (CCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the first tube, several analytes reached 10\/10 comparisons within the CAI (urea, sodium, potassium, calcium, magnesium, alkaline phosphatase, erythrocytes, hematocrit, MCV, leucocytes, thrombin time). Others showed 9\/10 comparisons (total protein, albumin, chloride, hemoglobin, thrombocytes, APTT, prothrombin time, fibrinogen). Only creatinine reached 8\/10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Discarding 1\u2009mL appeared sufficient for reliable testing after Kitelock\u2122 use in our cohort, but confirmation in larger studies is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298251403726","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:14:37Z","timestamp":1765779277000},"page":"1533-1544","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of an EDTA-based catheter lock solution on blood discard volume in PICC"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-7780","authenticated-orcid":false,"given":"Daniel","family":"Rajdl","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Hematology, University Hospital Pilsen and Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra Kab\u00e1tov\u00e1","family":"Maxov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, University Hospital Pilsen, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Chovancov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, University Hospital Pilsen, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Vodi\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, University Hospital Pilsen, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Bultasov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Hematology, University Hospital Pilsen and Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fejt","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Hematology, University Hospital Pilsen and Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Prokop","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Hematology, University Hospital Pilsen and Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Koldu\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Hematology, University Hospital Pilsen and Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0409-4916","authenticated-orcid":false,"given":"Jakub","family":"Klete\u010dka","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital Pilsen and Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-0602"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2024-0059"},{"key":"e_1_3_3_4_2","volume-title":"Collection of diagnostic venous blood specimens. 7th ed. 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