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This systematic review and Bayesian network meta-analysis synthesized available evidence by comparing different CLs directly and indirectly to prevent CLABSI and rank their effectiveness. A comprehensive search was performed across PubMed, Embase, Ovid, Scopus, Cochrane Library, and Google Scholar. After screening 2359 records by title and abstract and reviewing 374 full-text articles, 39 studies were included, covering seven CLs types. Bayesian network meta-analysis was conducted using STATA and ADDIS. Results showed that taurolidine-based (TCLs), ethanol-based (ECLs), gentamicin-based (GCLs), and EDTA-based (EDTA-CLs) solutions were more effective than saline or heparin in preventing CLABSI. According to the surface under the cumulative ranking curve (SUCRA), TCLs had the highest probability of reducing CLABSI (89.1%), followed by GCLs (82.6%) and EDTA-CLs (72.6%). 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