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However, inconsistencies in the literature, particularly regarding terminology and insertion techniques, have contributed to significant variability in clinical outcomes. To standardize and promote a safer and more effective insertion of these catheters, the Italian Group of Long-Term Venous Access Devices (GAVeCeLT) and the Italian Vascular Access Society (IVAS) have developed a six-step protocol that provides evidence-based recommendations. This insertion bundle\u2014named SILPeC (Safe Insertion of Long Peripheral Catheters\u2014includes (1) pre-insertion assessment of the vein of the upper limbs, (2) insertion of the optimal site selection, (3) appropriate measures of asepsis, (4) ultrasound-guided puncture, (5) safe connection to infusion lines, and (6) proper device stabilization and appropriate protection of the exit site. Integrating the latest scientific evidence and clinical expertise, the SILPeC bundle provides a standardized and reproducible method for placement and maintenance of LPCs. 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