{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:35:09Z","timestamp":1792924509711,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the effectiveness of the use of antimicrobial-impregnated neonatal peripherally inserted central catheters (AI n-PICC) compared to the use of standard n-PICC (S n-PICC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study was planned as prospective randomized controlled trial (open-label). Babies with a birth weight of less than 1500\u2009g in a 4-year period were included in the study. Newborns who needed a n-PICC were allocated randomly (1:1) to receive either an AI n-PICC (impregnated with miconazole and rifampicin) or a S n-PICC. The primary outcome was the incidence of central line-associated bloodstream infection (CLABSI), and secondarily, to assess reasons for catheter removal, and catheter duration times in these two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were a total of 254 infants from both groups during the study. The mean gestational age were 27.6\u2009\u00b1\u20092.8\u2009week in S group and 27.5\u2009\u00b1\u20092.8\u2009week in AI group. No significant differences observed in gestational age, birth weight, enteral feeding parameters, hospital stay, or antibiotic use duration (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The mean dwelling time was 14.2\u2009\u00b1\u20098.5\u2009day in S group and 15.4\u2009\u00b1\u20099.7\u2009day in AI group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      :0.293). The frequency of catheter withdrawal due to complications were 29.9% in the S group and 19.7% in the AI group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      :0.081). CLABSI rate (per 1000 catheter days) were found 9.44 in S group and 3.07 in AI group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      :0.013). The use of AI n-PICCs were associated with a 74% reduction in the hazard of catheter-related infection (HR\u2009=\u20090.26, 95% CI [0.09, 0.70],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study demonstrates that the use of AI n-PICCs was associated with a reduction in the rate of infection development in premature infants requiring n-PICC. The use of AI n-PICC may be effective especially in premature infants with a high risk of developing catheter-related infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298261472623","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:05:45Z","timestamp":1786446345000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of using standard versus antimicrobial-impregnated neonatal peripherally inserted central catheters in preterm infants: A single-center, prospective randomized controlled trial (open-label)"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-3056","authenticated-orcid":false,"given":"Ali","family":"Bulbul","sequence":"first","affiliation":[{"name":"Department of Neonatology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Science, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0283-0457","authenticated-orcid":false,"given":"Hasan","family":"Avsar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Science, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-2504","authenticated-orcid":false,"given":"Alper","family":"Divarci","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Science, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/11297298241291248"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0080-62342012000600030"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijnmr.ijnmr_20_21"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nedt.2024.106306"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/11297298241281640"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/526439"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.107247"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2021.6844"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2019.12.014"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213555"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2740-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00340-8"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30114-2"},{"issue":"6","key":"e_1_3_3_15_2","article-title":"Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants","volume":"6","author":"Gordon A","year":"2018","unstructured":"Gordon A, Greenhalgh M, McGuire W. Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants. Cochrane Database Syst Rev 2018; 6(6): CD012141.","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"e_1_3_3_16_2","article-title":"Antimicrobial-impregnated central venous catheters for prevention of catheter-related bloodstream infection in newborn infants","volume":"1","author":"Balain M","year":"2015","unstructured":"Balain M, Oddie SJ, McGuire W. Antimicrobial-impregnated central venous catheters for prevention of catheter-related bloodstream infection in newborn infants. Cochrane Database Syst Rev 2015; 1(9): CD011078.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15268"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2011.01.003"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(13)60012-2"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2021.09.016"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2018.07003"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2024.05.011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2024.04.011"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-024-01380-x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2021.07.004"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903214582"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2002.1358"},{"key":"e_1_3_3_28_2","unstructured":"Centers for Disease Control and Prevention. National Healthcare Safety Network (NHSN) Patient Safety Component Manual 2017 (Internet). Atlanta (GA): Centers for Disease Control and Prevention https:\/\/www.cdc.gov\/nhsn\/pdfs\/validation\/2017\/pcsmanual_2017.pdf (2017 accesed 1 September 2018)."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-021-00900-3"},{"key":"e_1_3_3_30_2","unstructured":"European Medicines Agency (EMA). Report on the Expert Meeting on Neonatal and Paediatric Sepsis London. London: EMA 2010 (updated 8 June 2010) https:\/\/www.ema.europa.eu\/en\/documents\/report\/report-expert-meeting-neonatal-and-paediatric-sepsis_en.pdf?utm_medium=email&utm_source=transaction (accessed 5 October 2025)."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-024-3184-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.5578\/ced.201957"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-044971"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2023.06.017"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1255492"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.1012800"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.4274\/tpa.46.61"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-190273"},{"issue":"6","key":"e_1_3_3_39_2","article-title":"Peripherally inserted central catheter design and material for reducing catheter failure and complications","volume":"6","author":"Schults JA","year":"2024","unstructured":"Schults JA, Kleidon T, Charles K, et al. Peripherally inserted central catheter design and material for reducing catheter failure and complications. Cochrane Database Syst Rev 2024; 6(6): CD013366.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.205"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2003.12.038"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000000963"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym12040939"},{"issue":"6","key":"e_1_3_3_44_2","first-page":"45","article-title":"Immobilization and death of bacteria by Flora Seal\u00ae microbial sealant","volume":"6","author":"Prince D","year":"2017","unstructured":"Prince D, Kohan K, Solanki Z, et al. Immobilization and death of bacteria by Flora Seal\u00ae microbial sealant. Int J Pharm Sci Invent 2017; 6(6): 45\u201349.","journal-title":"Int J Pharm Sci Invent"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir138"}],"container-title":["The Journal of Vascular Access"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11297298261472623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11297298261472623","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11297298261472623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:18:50Z","timestamp":1792923530000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11297298261472623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":45,"alternative-id":["10.1177\/11297298261472623"],"URL":"https:\/\/doi.org\/10.1177\/11297298261472623","relation":{},"ISSN":["1129-7298","1724-6032"],"issn-type":[{"value":"1129-7298","type":"print"},{"value":"1724-6032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"article-number":"11297298261472623"}}