{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:32:39Z","timestamp":1793863959169,"version":"4.6.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Peking University Third Hospital Innovation Transformation Fund \u201cChuying Program\u201d","award":["BYSYCY2024029"],"award-info":[{"award-number":["BYSYCY2024029"]}],"id":[{"id":"https:\/\/ror.org\/04wwqze12","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Central venous hemodialysis catheters are widely used in critically ill patients, but conventional double-lumen designs have limited functionality and are associated with high recirculation rates and thrombotic risk. Triple-lumen catheters can potentially meet the needs of simultaneous hemodialysis and intravenous therapy, yet their hemodynamic performance has not been systematically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A simplified superior vena cava (SVC)-catheter model was constructed. The Carreau non-Newtonian blood model was employed, and the Navier-Stokes equations were solved under mixed boundary conditions, including pulsatile SVC inflow and constant dialysis flow. A catheter flow rate of 400\u2009mL\/min was selected to represent a high-flow intermittent hemodialysis condition and to evaluate the catheter under a relatively demanding hemodynamic setting. Recirculation rate (RR) was calculated using Lagrangian particle tracking with 32,000 particles. Blood damage index (BDI) was calculated using the Grigioni power-law damage accumulation model with 1,400 platelet-sized particles. Wall shear stress (WSS) distribution was analyzed, and standard versus reversed connection configurations were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In standard connection, RR was 0.13%, mean BDI was 9.72\u2009\u00d7\u200910\u207b\n                      <jats:sup>4<\/jats:sup>\n                      , and high WSS (&gt;10 Pa) areas accounted for 1.22% of the total catheter wall surface. In reversed connection, RR was 0.10%, mean BDI was 8.16\u2009\u00d7\u200910\u207b\n                      <jats:sup>4<\/jats:sup>\n                      , and high WSS areas accounted for 1.71%. High shear stress was predominantly localized at side-hole edges and the distal tip.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A computational fluid dynamics (CFD) assessment framework was established for an acute, short-term, non-tunneled triple-lumen hemodialysis catheter for critically ill patients requiring temporary renal replacement therapy and an additional venous route. Under the single high-flow intermittent hemodialysis condition studied, the catheter demonstrated low recirculation, low BDI, and localized high WSS at side-hole edges and the distal tip. As comparator catheters were not simulated within the same framework, comparisons with prior literature are indirect and exploratory only. Direct comparator simulations and experimental validation are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11297298261477943","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:47:06Z","timestamp":1788277626000},"page":"2845-2852","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Computational fluid dynamics assessment of a triple-lumen hemodialysis catheter"],"prefix":"10.1177","volume":"27","author":[{"given":"Ming","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Civil and Transportation Engineering, Beijing University of Civil Engineering and Architecture, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbian","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liren","family":"Ban","sequence":"additional","affiliation":[{"name":"School of Civil and Transportation Engineering, Beijing University of Civil Engineering and Architecture, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4901-238X","authenticated-orcid":false,"given":"Zhen","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"2025 USRDS Annual Data Report: Epidemiology of kidney disease in the United States","author":"United States Renal Data System","year":"2025","unstructured":"United States Renal Data System. 2025 USRDS Annual Data Report: Epidemiology of kidney disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2025."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Ash SR. Fluid mechanics and clinical success of central venous catheters for dialysis: answers to simple but persisting problems. Semin Dial 2007; 20(3): 237\u2013256. https:\/\/doi.org\/10.1111\/j.1525-139X.2007.00284.x","DOI":"10.1111\/j.1525-139X.2007.00284.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Malek AM Alper SL Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA 1999; 282(21): 2035\u20132042. https:\/\/doi.org\/10.1001\/jama.282.21.2035","DOI":"10.1001\/jama.282.21.2035"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Mareels G De Wachter DS Verdonck P. Computational fluid dynamics-analysis of the Niagara hemodialysis catheter in a right heart model. 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