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In silico studies on broad-reactive antibodies and their interactions with hemagglutinins might shed light on the rational design of a universal vaccine. In this study, 11 broad-spectrum antibodies (or antigen-binding fragments) and 14 hemagglutinins of H3N2 and H5N1 strains were docked and analyzed to provide information about the construction of the scaffold for using universal antibodies against the influenza A virus. Antigen-binding fragments that have high number of appearances in the top 3 within each H3 and H5 subtypes were chosen for protein-protein interaction analysis. The results show that while the hydrogen bond is important for Ab\/Fab binding to H3, the H5-Ab\/Fab system may need cation-pi interaction for a strong interaction.<\/jats:p>","DOI":"10.1177\/1176934319876938","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T08:42:27Z","timestamp":1568623347000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Docking of Broad-Spectrum Antibodies on Hemagglutinins of Influenza A Virus"],"prefix":"10.1177","volume":"15","author":[{"given":"Khanh PB","family":"Le","sequence":"first","affiliation":[{"name":"School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-0816","authenticated-orcid":false,"given":"Phuc-Chau","family":"Do","sequence":"additional","affiliation":[{"name":"School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rommie E","family":"Amaro","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ly","family":"Le","sequence":"additional","affiliation":[{"name":"School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City, Vietnam"},{"name":"Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"bibr1-1176934319876938","first-page":"58","volume-title":"The Threat of Pandemic Influenza: Are We Ready? 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