{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:29:11Z","timestamp":1777465751804,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015339","name":"ACCP Foundation","doi-asserted-by":"publisher","award":["Futures Grants Program"],"award-info":[{"award-number":["Futures Grants Program"]}],"id":[{"id":"10.13039\/100015339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R00HL141685"],"award-info":[{"award-number":["R00HL141685"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R03AI152003"],"award-info":[{"award-number":["R03AI152003"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biomark\ufffdInsights"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Club cell secretory protein (CC16) has demonstrated utility as a lung-specific biomarker in predicting mortality in acute respiratory distress syndrome (ARDS). These findings have been observed in pre-clinical trials and a re-analysis of a large, randomized controlled trial of ARDS (Fluid and Catheter Treatment Trial (FACTT)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The purpose of this study was to validate previous findings by evaluating CC16 level as a mortality predictor in patients from the albuterol to treat acute lung injury (ALTA) trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Method:<\/jats:title>\n                    <jats:p>In this secondary biomarker analysis, plasma CC16 level was measured from 100 ALTA subjects using enzyme-linked immunosorbent assay (ELISA). The rate of mortality was assessed in patients with high (\u2a7e45\u2009ng\/mL) versus low CC16 (&lt;45\u2009ng\/mL) levels. This cut-off level was applied based on our previous analysis from FACTT trial. Significance was assessed using Kaplan-Meier curves and a log-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Subjects were an average of 50\u2009years old and 46% of them were females. Patients with high CC16 levels had higher 90-day mortality compared to those with low CC16 levels, (37.73% vs 8.95%, P\u2009&lt;\u2009.001). Other clinical outcomes including ICU-free days, ventilator-free days, and organ failure free days were significantly different between the groups (All P\u2009&lt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this validation study, we demonstrated that ARDS patients with high plasma CC16 concentration had a higher mortality rate than those with low CC16 levels, confirming previous findings that CC16 levels are associated with ARDS mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11772719231156308","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T06:12:00Z","timestamp":1676614320000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Validation of Prognostic Club Cell Secretory Protein (CC16) Cut-point in an Independent ALTA Cohort"],"prefix":"10.1177","volume":"18","author":[{"given":"Sultan","family":"Almuntashiri","sequence":"first","affiliation":[{"name":"Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA"},{"name":"Department of Clinical Pharmacy, College of Pharmacy, University of Hail, Hail, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Chase","sequence":"additional","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA, USA"},{"name":"Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Sikora","sequence":"additional","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy, College of Pharmacy, University of Georgia, Augusta, GA, USA"},{"name":"Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-4174","authenticated-orcid":false,"given":"Duo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA"},{"name":"Department of Medicine, Augusta University, Augusta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"bibr1-11772719231156308","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06035-0"},{"key":"bibr2-11772719231156308","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124039"},{"key":"bibr3-11772719231156308","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22262"},{"key":"bibr4-11772719231156308","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01245-0"},{"key":"bibr5-11772719231156308","volume":"17","author":"Ware LB","year":"2013","journal-title":"Crit 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