{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:51:55Z","timestamp":1793843515070,"version":"4.6.1"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biomark\ufffdInsights"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although, several studies have assessed the association of the phospholipase A2 receptor (PLA2R) and HLA-DQA1 SNPs with primary membranous nephropathy (PMN), results were inconsistent and between-studies heterogeneity needs to be investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this review was to summarize existing data on the contribution of 10 SNPs in the PLA2R and HLA-DQA1 genes to PMN susceptibility and to investigate the between-studies heterogeneity by subgroup analyses and meta-regressions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This study was performed according to the PRISMA guidelines for systematic reviews and meta-analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources and methods:<\/jats:title>\n                    <jats:p>An electronic literature search for eligible studies among all papers published prior to January 10, 2024, was conducted through PubMed, EMBASE, Web of science and Scopus databases. Meta-analyses together with subgroup analyses and meta-regressions were performed for the 10 following SNPs: rs4664308, rs3749117, rs3749119, rs35771982, rs3828323, rs16844715, rs1511223, rs6757188, rs2715918, and rs2187668.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Combined analyses revealed a significant increase in PMN risk conferred by the following alleles: rs4664308*A, rs3749117*T, rs3749119*C, rs35771982*G, rs3828323*C, rs16844715*C, rs1511223*A, rs2715918*A, and rs2187668*A, all P-values\u2009&lt;\u2009.001. Moreover, the PLA2R-rs4664308\/HLA-DQA1-rs2187668 interaction was significantly associated with an increased PMN risk, P\u2009&lt;\u2009.001. However, there was a substantial between-studies heterogeneity for some SNPs. Subgroup analyses by ethnicity for the 9 PLA2R SNPs did not show any cross-ethnic disparity. Inversely, the risk conferred by the HLA-DQA1 rs2187668*A allele was significantly higher in Caucasians (OR [95% CI]\u2009=\u20093.929 [3.251\u20134.748]) than in Asians (OR [95% CI]\u2009=\u20092.537 [1.94\u20133.318], P\u2009=\u2009.007. Besides, meta-regressions revealed for the majority of investigated SNPs significant correlations of the effect size with albumin, 24-hours proteinuria, serum creatinine, and eGFR levels. Hence, the influence on PMN risk conferred by the PLA2R and HLA-DQA1 SNPs was rather noted in patients with a severe disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This meta-analysis showed that 9 out of the 10 investigated SNPs in PLA2R and HLA-DQA1 genes were associated with increased PMN risk. Heterogeneity could be due to disparate patient groups in terms of disease presentation for almost all SNPs, and ethnicity for the HLA-DQA1 rs2187668 SNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>This review has been registered on PROSPERO: CRD42024506729. Available from: https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42024506729<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11772719241259602","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T07:48:54Z","timestamp":1718005734000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of 10 Polymorphisms in PLA2R1 and HLA DQA1 Genes with Primary Membranous Nephropathy Risk: A Meta-Analysis and a Meta-Regression"],"prefix":"10.1177","volume":"19","author":[{"given":"Tarak","family":"Dhaouadi","sequence":"first","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awatef","family":"Riahi","sequence":"additional","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u00efeb Ben","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousr","family":"Gorgi","sequence":"additional","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Sfar","sequence":"additional","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"bibr1-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015111262"},{"key":"bibr2-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1016\/j.nephro.2013.10.002"},{"key":"bibr3-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810457"},{"key":"bibr4-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.07.014"},{"key":"bibr5-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.209"},{"key":"bibr6-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022908"},{"key":"bibr7-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70009-x"},{"key":"bibr8-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013031"},{"key":"bibr9-11772719241259602","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2011.300630"},{"key":"bibr10-11772719241259602","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj046"},{"key":"bibr11-11772719241259602","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. 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