{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:24:06Z","timestamp":1792103046871,"version":"4.4.0"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005189","name":"estonian research competency council","doi-asserted-by":"publisher","award":["PRG1255"],"award-info":[{"award-number":["PRG1255"]}],"id":[{"id":"10.13039\/501100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biomark&amp;#65533;Insights"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute mesenteric venous thrombosis (MVT) is rarely suspected as primary diagnosis in emergency departments and still carries an in-hospital mortality rate of above 20%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this study was to find differences in clinical and laboratory markers between patients with acute MVT and a control group of suspected but confirmed as not having any type of acute mesenteric ischaemia (AMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Data was retrieved from the AMESI (Acute MESenteric Ischaemia) study. This international, multicenter prospective case-control study from 32 sites collected data on patients with suspected AMI during a 10-month period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Independent factors associated with acute MVT were evaluated in a multivariable logistic regression analysis and expressed as odds ratios (OR) with 95%\u2009confidence intervals\u2009(CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      D-dimer was not significantly higher in MVT (n\u2009=\u200973) compared to non-AMI (n\u2009=\u2009287) patients (median 7.0\u2009mg\/L\u2009vs\u20094.5\u2009mg\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.092). After entering BMI, atherosclerotic disease, history of venous thromboembolism, CRP, and D-dimer as covariates in a multi-variable logistic regression analysis, absence of atherosclerotic disease (OR 0.096, 95%\u2009CI 0.011-0.84;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.034) and elevated D-dimer (OR 2.59\/one SD increment, 95%\u2009CI 1.07-6.28;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.034) were associated with MVT. The discriminative ability of D-dimer for MVT as assessed by area under the curve in the receiver operating characteristics analysis was 0.63 (95%\u2009CI 0.49-0.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Elevated D-dimer was associated with MVT, but the discriminative ability of D-dimer was poor. There is an urgent need to find a more accurate plasma biomarker for this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION:<\/jats:title>\n                    <jats:p>NCT05218863 (registered 19.01.2022).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11772719241296631","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T04:14:16Z","timestamp":1732594456000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["D-Dimer in Acute Mesenteric Venous Thrombosis: A Prospective Case-Control International Multicenter Study"],"prefix":"10.1177","volume":"19","author":[{"given":"Stefan","family":"Acosta","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6, Lund University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika Reintam","family":"Blaser","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tartu, Estonia"},{"name":"Department of Intensive Care Medicine, Lucerne Cantonal Hospital, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Nuzzo","sequence":"additional","affiliation":[{"name":"Intestinal Stroke Center, Department of Gastroenterology, IBD and Intestinal Failure, AP-HP. Nord, Beaujon Hospital, Paris Cit\u00e9 University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Soltanzadeh-Naderi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6, Lund University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Starkopf","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tartu, Estonia"},{"name":"Tartu University Hospital, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Forbes","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Murruste","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tartu, Estonia"},{"name":"Tartu University Hospital, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-0417","authenticated-orcid":false,"given":"Kadri","family":"Tamme","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tartu, Estonia"},{"name":"Tartu University Hospital, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Liisa","family":"Voomets","sequence":"additional","affiliation":[{"name":"Tartu University Hospital, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merli","family":"Koitm\u00e4e","sequence":"additional","affiliation":[{"name":"Estonian Genome Center, Institute of Genomics, University of Tartu, Estonia"},{"name":"Institute of Mathematics and Statistics, University of Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miklosh","family":"Bala","sequence":"additional","affiliation":[{"name":"Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Bodnar","sequence":"additional","affiliation":[{"name":"Letterkenny University Hospital, Letterkenny, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-0804","authenticated-orcid":false,"given":"Dumitru","family":"Casian","sequence":"additional","affiliation":[{"name":"Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-9684","authenticated-orcid":false,"given":"Zaza","family":"Demetrashvili","sequence":"additional","affiliation":[{"name":"N. Kipshidze Central University Hospital, Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Biloslavo","sequence":"additional","affiliation":[{"name":"University Hospital of Trieste ASUGI, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia D\u00faran","family":"Mu\u00f1oz-Cruzado","sequence":"additional","affiliation":[{"name":"Virgen del Roc\u00edo University Hospital, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Lucerne Cantonal Hospital, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karri","family":"Kase","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Kirov","sequence":"additional","affiliation":[{"name":"Northern State Medical University and City Hospital #1, Arkhangelsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lindner","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia I","family":"Loudet","sequence":"additional","affiliation":[{"name":"Hospital General San Martin de La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Damaskos","sequence":"additional","affiliation":[{"name":"Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bj\u00f6rck","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Tartu, Estonia"},{"name":"Department of Surgical Sciences, Vascular surgery, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"AMESI Investigators (Collaborators) Olivier Corcos, Yves Castier, Maxime Ronot, Mario D\u2019Oria, Lucia Paiano, Gunnar Elke, Denise Nagel, David I. 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