{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T07:30:29Z","timestamp":1794555029633,"version":"4.9.1"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008731","name":"nakatomi foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"takeda science foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005928","name":"daiwa securities health foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008728","name":"japan research foundation for clinical pharmacology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008734","name":"mitsui sumitomo insurance welfare foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"bristol-myers squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"japan agency for medical research and development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Hospital Organization"},{"DOI":"10.13039\/501100003478","name":"ministry of health, labour and welfare","doi-asserted-by":"publisher","award":["22591090, 26293123, 15K09543, 18K08402"],"award-info":[{"award-number":["22591090, 26293123, 15K09543, 18K08402"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["24791018"],"award-info":[{"award-number":["24791018"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biomark\ufffdInsights"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) is complicated with interstitial lung disease (ILD). Gastroesophageal reflux disease is prevented by Helicobacter pylori infection and is a predisposing factor for idiopathic pulmonary fibrosis. However, the prevalence of H.\u2009pylori infection in RA patients with ILD has not been sufficiently investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In this study, we analyzed anti- H.\u2009pylori antibodies in RA patients with ILD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Case-control observational study<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Anti- H.\u2009pylori antibodies were analyzed in the sera of RA patients using a commercially available enzyme-linked immunosorbent assay kit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The positivity of anti- H.\u2009pylori antibodies in RA with ILD ( n\u2009=\u200930 [18.0%], P\u2009=\u2009.0227), usual interstitial pneumonia ( n\u2009=\u200910 [14.3%], P\u2009=\u2009.0212), and airway disease ( n\u2009=\u200930 [18.0%], P\u2009=\u2009.0227) was significantly lower than that of RA without chronic lung disease ( n\u2009=\u200978 [27.5%]). The positivity of anti- H.\u2009pylori antibodies was also lower in RA with chronic lung disease ( n\u2009=\u200968 [18.2%], P\u2009=\u2009.0059). Multiple logistic regression analyses showed that the presence of anti- H.\u2009pylori antibodies was independently and protectively associated with chronic lung disease in RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The seroprevalence of H.\u2009pylori was lower in RA with ILD. H.\u2009pylori infection prevented ILD in patients with RA by protecting them from gastroesophageal reflux disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11772719241297171","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T01:16:31Z","timestamp":1733361391000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Helicobacter pylori<\/i>\n                    Seroprevalence in Rheumatoid Arthritis Patients with Interstitial Lung Disease"],"prefix":"10.1177","volume":"19","author":[{"given":"Shomi","family":"Oka","sequence":"first","affiliation":[{"name":"Department of Rheumatology, NHO Tokyo National Hospital, Kiyose, Japan"},{"name":"Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Tokyo National Hospital, Kiyose, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Tokyo National Hospital, Kiyose, Japan"},{"name":"Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, NHO Sagamihara National Hospital, Minami-ku, Sagamihara, Japan"},{"name":"Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu, 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Japan"},{"name":"Department of Clinical Laboratory, NHO Sagamihara National Hospital, Minami-ku, Sagamihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Saisho","sequence":"additional","affiliation":[{"name":"Department of Orthopedics\/Rheumatology, NHO Miyakonojo Medical Center, Miyakonojo, Japan"},{"name":"Tanimura Hospital, Nobeoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Tanimura Hospital, Nobeoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, NHO Nagoya Medical Center, Naka-ku, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Matsui","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara 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