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Evidence suggests that HBPs present on Leishmania surface participate in the adhesion and invasion of parasites to tissues of both invertebrate and vertebrate hosts. In this study, we identified the product with an HSP90 (heat shock protein 90) domain encoded by lipophosphoglycan ( LPG3) gene as a L infantum chagasi HBP (HBP Lc). Structural analysis using the LPG3 recombinant protein suggests that it is organized as a tetramer. Binding analysis confirms that it is capable of binding heparin with micromolar affinity. Inhibition of adenosine triphosphatase activity in the presence of heparin, molecular modeling, and in silico docking analysis suggests that heparin-binding site superimposes with the adenosine triphosphate\u2013binding site. Together, these results show new properties of LPG3 and suggest an important role in leishmaniasis.<\/jats:p>","DOI":"10.1177\/1177932218763363","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T01:40:24Z","timestamp":1520991624000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Lipophosphoglycan 3 From\n                    <i>Leishmania infantum chagasi<\/i>\n                    Binds Heparin With Micromolar Affinity"],"prefix":"10.1177","volume":"12","author":[{"given":"Tha\u00eds Viana Fialho","family":"Martins","sequence":"first","affiliation":[{"name":"Departamento de Biologia Geral, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Eliza","family":"Zeraik","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, 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