{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:57:48Z","timestamp":1785571068978,"version":"3.56.0"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005150","name":"chinese academy of medical sciences","doi-asserted-by":"publisher","award":["2024-RW310-01"],"award-info":[{"award-number":["2024-RW310-01"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bioinform Biol Insights"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Hepatocellular carcinoma (HCC) is a common malignant tumor with a poor prognosis for advanced metastasis while there is currently a lack of prognostic markers and effective therapeutic targets in this area. The\n                    <jats:italic toggle=\"yes\">PSD<\/jats:italic>\n                    gene family, comprising four genes, has been implicated in tumor metastasis in breast cancer, but its role in HCC remains unclear. To elucidate the role-played by the\n                    <jats:italic toggle=\"yes\">PSD<\/jats:italic>\n                    gene family in the prognosis of HCC and explore the relationship between the\n                    <jats:italic toggle=\"yes\">PSD<\/jats:italic>\n                    gene family and tumor metastasis, we conducted a bioinformatics analysis using TCGA and gene expression omnibus (GEO) databases to investigate\n                    <jats:italic toggle=\"yes\">PSD<\/jats:italic>\n                    gene family expression in HCC and its correlation with patient survival. Furthermore, we performed quantitative real-time polymerase chain reaction (qPCR) validation of the expression levels of the\n                    <jats:italic toggle=\"yes\">PSD<\/jats:italic>\n                    gene family in clinical samples. Gene correlation and enrichment analyses were also performed to explore its relationship with tumor metastasis. In conclusion, the expression levels of the\n                    <jats:italic toggle=\"yes\">PSD<\/jats:italic>\n                    gene family are significantly downregulated in HCC (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.01), and the lower expressions are associated with poor survival. In addition, there is a link between the\n                    <jats:italic toggle=\"yes\">PSD<\/jats:italic>\n                    gene family and RAS pathway activation, suggesting its potential role in metastasis.\n                  <\/jats:p>","DOI":"10.1177\/11779322261425454","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:34:56Z","timestamp":1785389696000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinformatics Analysis of the PSD Gene Family: Metastasis and Prognosis in HCC"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8289-4586","authenticated-orcid":false,"given":"Hongyi","family":"Sun","sequence":"first","affiliation":[{"name":"School of Nursing, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Science, Tibet University, Lhasa, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Science, Tibet University, Lhasa, China"},{"name":"Department of Human Anatomy and Histoembryology, Institute of Basic Medical Sciences, School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.2996"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i22.2348"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(05)80587-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12182303"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.05.014"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.655697"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00620-y"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.09.051"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6633\/ab1628"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-14-0298"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22522-4"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01821-6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.209361"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i3.289"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07016-7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12477"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2022.05.002"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.007"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00391"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4092"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2022.04.003"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-748-8_18"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz757"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03315"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-17-0307"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1000"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.010"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00790-2"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2018.06.004"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13226"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3233\/cbm-220454"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.10.003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1517"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.60885"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.2147\/jhc.S452924"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5110"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-94504-1"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.10.018"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2019.103968"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gande.2024.06.001"}],"container-title":["Bioinformatics and Biology Insights"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11779322261425454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11779322261425454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11779322261425454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:18:28Z","timestamp":1785568708000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11779322261425454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":48,"alternative-id":["10.1177\/11779322261425454"],"URL":"https:\/\/doi.org\/10.1177\/11779322261425454","relation":{},"ISSN":["1177-9322","1177-9322"],"issn-type":[{"value":"1177-9322","type":"print"},{"value":"1177-9322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"11779322261425454"}}