{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:20:48Z","timestamp":1777454448500,"version":"3.51.4"},"reference-count":132,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bioinform Biol Insights"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Dabie bandavirus<\/jats:italic>\n                    (DBV), also called severe fever with thrombocytopenia syndrome virus (SFTSV), is a tick-borne virus that leads to a serious illness with high fever, low platelets, bleeding risks, and organ damage. Death rates can reach 5% to 30% in affected areas like China, South Korea, and Japan, where cases continue to rise. No approved vaccines or specific treatments are available, prompting the World Health Organization to mark it as a priority emerging infectious disease. This in silico study designs a multi-epitope mRNA vaccine candidate targeting the virus\u2019s membrane glycoprotein. After reviewing 1042 virus sequences, 9 cytotoxic T-cell (cytotoxic T lymphocyte [CTL]), 6 helper T-cell (helper T lymphocyte [HTL]), and 5 B-cell epitopes were chosen for their high conservation, predicted antigenicity, safety (non-toxic, low allergenicity), and lack of similarity to human proteins, achieving 94.77% global population coverage. The construct included beta-defensin-3 as an adjuvant. Computational predictions indicated favorable features: structural stability, potential binding to immune receptors (Toll-like receptor 3 [TLR3] and Toll-like receptor 4 [TLR4]), consistent behavior in molecular dynamics simulations (100 ns), encouraging patterns in immune response modeling, and good codon optimization for possible expression. These results are hypothesis-generating and based solely on in silico tools and require experimental validation, including in vitro studies, immunogenicity tests, and animal challenge models to assess any real-world potential.\n                  <\/jats:p>","DOI":"10.1177\/11779322261438994","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:47:17Z","timestamp":1776055637000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-Epitope mRNA Vaccine Targeting\n                    <i>Dabie Bandavirus<\/i>\n                    Glycoprotein: An Immunoinformatics-Based Study"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9299-1240","authenticated-orcid":false,"given":"Sk Faisal","family":"Ahmed","sequence":"first","affiliation":[{"name":"DawniLab, Dawn of Bioinformatics Ltd., Dhaka, 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