{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:13:29Z","timestamp":1788534809036,"version":"build-2803163510"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["52372262"],"award-info":[{"award-number":["52372262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82203464"],"award-info":[{"award-number":["82203464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bioinform Biol Insights"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer (CRC), but how chronic intestinal inflammation drives malignant transformation remains unclear. We retrospectively reanalyzed published single-cell transcriptomic datasets from intestinal biopsies of healthy individuals and patients with IBD; differential expression was assessed using independent t tests with Benjamini\u2013Hochberg false discovery rate correction. We then integrated those single-cell findings with the Cancer Genome Atlas bulk transcriptomes and pharmacogenomic cohorts to trace stromal programs across the IBD-to-cancer continuum. ARHGEF15 emerged as a stromal gene enriched in CD74\n                    <jats:sup>hi<\/jats:sup>\n                    HLA-DRB1\n                    <jats:sup>hi<\/jats:sup>\n                    arterial pericytes within inflamed tissue. Its expression rose steadily from IBD to CRC and tracked with epithelial\u2013mesenchymal transition (EMT) activity. In CRC, higher ARHGEF15 expression was associated with shorter overall and progression-free survival. These retrospective, in silico findings identify ARHGEF15 as an exploratory stromal biomarker associated with inflammatory EMT and stromal\u2013immune remodeling during IBD-to-CRC progression. Prospective experimental and clinical validation is required to establish its prognostic or therapeutic relevance.\n                  <\/jats:p>","DOI":"10.1177\/11779322261483612","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:11:16Z","timestamp":1788261076000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stromal ARHGEF15 Correlates With Inflammatory EMT and Stromal-Immune Crosstalk During Inflammatory Bowel Disease-To-Colorectal Cancer Progression"],"prefix":"10.1177","volume":"20","author":[{"family":"GuoliangLi","sequence":"first","affiliation":[{"name":"Peking University People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2408-8611","authenticated-orcid":false,"given":"Xiangxiang","family":"Hao","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaowen","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshuai","family":"Wu","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3815-5799","authenticated-orcid":false,"given":"Hongpeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00966-2"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1704651"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00953-0"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1403718"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311003"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.526"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaf043"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab291"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14080567"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-026-02970-y"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051136"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1397-4"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.029"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.067"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0096-5"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-024-09941-9"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.adcanc.2026.100185"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-026-08413-w"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07571-1"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045858"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-016-0516-4"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02560-6"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci85504"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina54010008"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology14070756"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030286"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.550879"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2003.10.006"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.10.007"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13516"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9120171"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24485"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123435"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3413-3"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02593-8"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-026-08232-9"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300344RRR"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1510"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.116049"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193810"}],"container-title":["Bioinformatics and Biology Insights"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11779322261483612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11779322261483612","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11779322261483612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:17:47Z","timestamp":1788531467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11779322261483612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":42,"alternative-id":["10.1177\/11779322261483612"],"URL":"https:\/\/doi.org\/10.1177\/11779322261483612","relation":{},"ISSN":["1177-9322","1177-9322"],"issn-type":[{"value":"1177-9322","type":"print"},{"value":"1177-9322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"11779322261483612"}}