{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:12:56Z","timestamp":1777936376248,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Subst\ufffdAbuse"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess protein expression of \u03b17 and \u03b14 nicotinic acetylcholine receptors (nAChR) subtypes in squamous cell carcinoma of the upper aerodigestive track (out of the larynx) according to tobacco smoke exposure, considering the general characteristics of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The \u03b17 and \u03b14 nAChR subtypes were assessed by immunohistochemistry in tumor samples from 33 patients with novel diagnosis of squamous cell carcinoma of the upper aerodigestive tract (out of the larynx).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Current smokers were middle-age men with alcohol consumption, whereas elderly women with no alcohol consumption prevailed among nonsmokers. Expression of \u03b14 nAChR was high in all groups, with an influence of alcohol use, although expression of \u03b17 nAChR was low in current smokers with alcohol use. Expression of \u03b14 with no expression of \u03b17 nAChR was associated with advanced disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Squamous cell carcinoma tumors of the upper aerodigestive tract (out of the larynx) may show desensitization of \u03b14 nAChR. Advanced disease at diagnosis might be associated with desensitization of \u03b14 with decrease in \u03b17 nAChR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1178221818801316","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T02:21:11Z","timestamp":1556677271000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Tobacco Smoke Exposure on the Protein Expression of \u03b17 and \u03b14 Nicotinic Acetylcholine Receptors in Squamous Cell Carcinoma Tumors of the Upper Aerodigestive Tract (Out of the Larynx)"],"prefix":"10.1177","volume":"12","author":[{"given":"Bertha B","family":"Monta\u00f1o-Vel\u00e1zquez","sequence":"first","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda, CMN La Raza, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C","family":"Benavides M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda, CMN La Raza, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J","family":"Garc\u00eda-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Patol\u00f3gica, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Conde-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda, CMN La Raza, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"S\u00e1nchez-Uribe","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, HE CMN La Raza, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia R","family":"Taboada-Murrieta","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, HE CMN La Raza, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-1422","authenticated-orcid":false,"given":"Kathrine","family":"J\u00e1uregui-Renaud","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Otoneurolog\u00eda, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"bibr1-1178221818801316","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"bibr2-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1549"},{"key":"bibr3-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh014"},{"key":"bibr4-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-13-0541"},{"key":"bibr5-1178221818801316","first-page":"195","volume":"9","author":"Schuller H.","year":"2009","journal-title":"Nature Rev"},{"key":"bibr6-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02702-8"},{"key":"bibr7-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1007\/BF00167110"},{"key":"bibr8-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.041756"},{"key":"bibr9-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00526.x"},{"key":"bibr10-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.05.003"},{"key":"bibr11-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X09106326"},{"key":"bibr12-1178221818801316","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090212"},{"key":"bibr13-1178221818801316","first-page":"835","volume":"27","author":"Carracedo DG","year":"2007","journal-title":"Anticancer Res"},{"key":"bibr14-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.052274"},{"key":"bibr15-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1159\/000445781"},{"key":"bibr16-1178221818801316","first-page":"507","volume":"32","author":"Tap\u00eda-Conyemr R","year":"1990","journal-title":"Salud Publ Mex"},{"key":"bibr17-1178221818801316","volume-title":"Pathology and Genetics of Head and Neck Tumours: WHO Classification of tumors","author":"Barnes L","year":"2005"},{"key":"bibr18-1178221818801316","first-page":"1010","volume":"50","author":"Yu D","year":"1996","journal-title":"Mol Pharmacol"},{"key":"bibr19-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02593-9"},{"key":"bibr20-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04135.x"},{"key":"bibr21-1178221818801316","first-page":"774","volume":"289","author":"Cardoso RA","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr22-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0154-16.2016"},{"key":"bibr23-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503163321104"},{"key":"bibr24-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e84652"},{"key":"bibr25-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890030006001"},{"key":"bibr26-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2009.05.013"},{"key":"bibr27-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.09.011"},{"key":"bibr28-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)59044-X"},{"key":"bibr29-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(90)90089-T"},{"key":"bibr30-1178221818801316","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199704000-00017"}],"container-title":["Substance Abuse: Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1178221818801316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1178221818801316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1178221818801316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:29:11Z","timestamp":1777692551000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1178221818801316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":30,"alternative-id":["10.1177\/1178221818801316"],"URL":"https:\/\/doi.org\/10.1177\/1178221818801316","relation":{},"ISSN":["1178-2218","1178-2218"],"issn-type":[{"value":"1178-2218","type":"print"},{"value":"1178-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"article-number":"1178221818801316"}}