{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:13:12Z","timestamp":1777936392304,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Subst\ufffdAbuse"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Opioid maintenance treatment (OMT) is the standard for treatment of opioid use disorder, but some individuals on OMT experience disrupted sleep, heightened sensitivity to pain, and continued relapse to non-medical opioid use. An adjunctive treatment that has potential to address these shortcomings of OMT is aerobic exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of the present review was to identify and evaluate components of aerobic exercise interventions targeting OMT patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>For this PROSPERO-registered review (ID CRD42020139626), studies were identified via electronic bibliographic databases, funded research ( NIH RePORTER) and clinical trials databases ( ClinicalTrials.gov), and reference sections of relevant manuscripts. Studies that evaluated the effects of an aerobic exercise intervention using a comparison condition or pretest-posttest design in adult OMT patients were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 2971 unique records, three primary studies and one supplemental manuscript comprised the final sample. All studies were randomized trials involving supervised exercise interventions enrolling small samples of middle-aged OMT patients. Exercise interventions included a variety of aerobic and non-aerobic activities (e.g. flexibility exercises), and none controlled the dose of aerobic exercise. Few studies used objective measures of physical activity or cardiorespiratory fitness and there were no significant effects of adjunctive exercise on substance use outcomes, but tests of the latter were likely underpowered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Though early in the accumulation of evidence, interventions targeting aerobic exercise for OMT patients appear feasible, acceptable to patients, and beneficial. Longer-term studies that employ larger samples, include assessments of behavioral and biological mechanisms of change, more rigorous measurement of physical activity, and controlled doses of aerobic activity are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1178221820918885","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T14:20:28Z","timestamp":1591885228000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Aerobic Exercise Interventions for Patients in Opioid Maintenance Treatment: A Systematic Review"],"prefix":"10.1177","volume":"14","author":[{"given":"Danielle E","family":"Jake-Schoffman","sequence":"first","affiliation":[{"name":"Department of Health Education and Behavior, College of Health and Human Performance, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith S","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Health Education and Behavior, College of Health and Human Performance, University of Florida, Gainesville, FL, USA"},{"name":"Department of Psychology, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa L","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Health Education and Behavior, College of Health and Human Performance, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetra D","family":"Christou","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Dallery","sequence":"additional","affiliation":[{"name":"Department of Psychology, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-6454","authenticated-orcid":false,"given":"Jillian M","family":"Rung","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Health Professions & College of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"bibr1-1178221820918885","unstructured":"Center for Behavioral Health Statistics and Quality. Key Substance Use and Mental Health Indicators in the United States: Results from the 2018 National Survey on Drug Use and Health. Rockville, MD; 2019. https:\/\/www.samhsa.gov\/data\/report\/2018-nsduh-annual-national-report"},{"key":"bibr2-1178221820918885","unstructured":"National Institute on Drug Abuse. Overdose death rates. 2019. https:\/\/www.drugabuse.gov\/related-topics\/trends-statistics\/overdose-death-rates. Accessed September 16, 2019."},{"key":"bibr3-1178221820918885","unstructured":"Center for Behavioral Health Statistics and Quality. Treatment Episode Data Set (TEDS): 2017. Admissions to and Discharges from Publicly-Funded Substance Use Treatment. Rockville, MD; 2019. https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/cbhsq-reports\/TEDS-2017.pdf"},{"key":"bibr4-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000075"},{"key":"bibr5-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12430"},{"key":"bibr6-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(00)00200-3"},{"key":"bibr7-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00306-2"},{"key":"bibr8-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.10.010"},{"key":"bibr9-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.07.016"},{"key":"bibr10-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2005.08.011"},{"key":"bibr11-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(03)00191-0"},{"key":"bibr12-1178221820918885","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2018.0526"},{"key":"bibr13-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2016.1179705"},{"key":"bibr14-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.10.020"},{"key":"bibr15-1178221820918885","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2016.00080"},{"key":"bibr16-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2016.08.026"},{"key":"bibr17-1178221820918885","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00082"},{"key":"bibr18-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2008.11.001"},{"key":"bibr19-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(12)70891-5"},{"key":"bibr20-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.05.044"},{"key":"bibr21-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2019.04.001"},{"key":"bibr22-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110728"},{"key":"bibr23-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2012.663327"},{"key":"bibr24-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.09.006"},{"key":"bibr25-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1364387"},{"key":"bibr26-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/20.3.203"},{"key":"bibr27-1178221820918885","unstructured":"Centers for Disease Control and Prevention. Physical activity for a healthy weight. Healthy weight. 2015. https:\/\/www.cdc.gov\/healthyweight\/physical_activity\/index.html. Accessed October 10, 2019."},{"key":"bibr28-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12336"},{"issue":"2","key":"bibr29-1178221820918885","first-page":"137","volume":"20","author":"Barry DT","year":"2011","journal-title":"Am J Addict"},{"key":"bibr30-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2012.10.002"},{"key":"bibr31-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0439-1"},{"key":"bibr32-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.mhpa.2013.02.001"},{"key":"bibr33-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2014.890765"},{"key":"bibr34-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr35-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2017.01.012"},{"issue":"3","key":"bibr36-1178221820918885","first-page":"41","volume":"20","author":"Staub L","year":"2018","journal-title":"Heroin Addict Relat Clin Probl"},{"key":"bibr37-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2014.05.007"},{"key":"bibr38-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-965129"},{"key":"bibr39-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"bibr40-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.06.016"},{"key":"bibr41-1178221820918885","first-page":"1","volume":"4","author":"Thiebaud RS","year":"2018","journal-title":"Digit Heal"},{"key":"bibr42-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1177\/1559827619862179."},{"key":"bibr43-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2014.03.004"},{"key":"bibr44-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1016\/j.mhpa.2013.09.004"},{"key":"bibr45-1178221820918885","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1762-x"}],"container-title":["Substance Abuse: Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1178221820918885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1178221820918885","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1178221820918885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:29:39Z","timestamp":1777692579000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1178221820918885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":45,"alternative-id":["10.1177\/1178221820918885"],"URL":"https:\/\/doi.org\/10.1177\/1178221820918885","relation":{},"ISSN":["1178-2218","1178-2218"],"issn-type":[{"value":"1178-2218","type":"print"},{"value":"1178-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1178221820918885"}}