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An esophagogastroduodenoscopy (EGD) was performed and confirmed the diagnosis of a large duodenal ulcer. Neratinib was stopped, and the patient was treated with a proton pump inhibitor. Repeat EGD performed 3 months later showed complete resolution of the duodenal ulcer. Given this unexpected serious adverse event and only modest benefit of neratinib in the adjuvant setting, the decision was made to forgo further treatment with neratinib. Physicians should be aware of the gastrointestinal (GI) side effects associated with neratinib and recognize that peptic ulcer disease may be another GI toxicity associated with neratinib use.<\/jats:p>","DOI":"10.1177\/1178223420935871","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T01:56:07Z","timestamp":1592963767000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neratinib-Induced Duodenal Ulcer: A Case Report"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0860-0441","authenticated-orcid":false,"given":"Bahar","family":"Moftakhar","sequence":"first","affiliation":[{"name":"Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Kharel","sequence":"additional","affiliation":[{"name":"Geisinger Medical Center, Danville, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujan","family":"Niraula","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Sciences (IAHS), Chittagong, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shipra","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Falkson","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"bibr1-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1978"},{"key":"bibr2-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30717-9"},{"key":"bibr3-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00551-3"},{"key":"bibr4-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.8707"},{"key":"bibr5-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513750"},{"key":"bibr6-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0237"},{"key":"bibr7-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01511"},{"key":"bibr8-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0900"},{"key":"bibr9-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-018-0719-0"},{"key":"bibr10-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1354986"},{"key":"bibr11-1178223420935871","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr12-1178223420935871","unstructured":"The use of the WHO-UMC system for standardized case causality assessment. 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