{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:22:11Z","timestamp":1777454531068,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Breast Cancer\ufffd(Auckl)"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Sentinel lymph node biopsy (SLNB) of the axilla is standard in breast cancer (BC) management; however, its role in prophylactic\/contralateral prophylactic mastectomy (CPM) is still questioned. To avoid future consequences on surgical morbidity and socioeconomic aspects in low and middle-income countries (LMICs), we intend to determine the prevalence of occult breast cancer (OBC) among CPM cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the prevalence of OBC in patients undergoing prophylactic mastectomy (PM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study is conducted at a tertiary-care hospital from January 2017 to December 2022. All individuals with the positive genetic test for high-risk breast cancer (HRBC) genes who underwent PMs\/CPM at our centre were included. We analysed data using SPSS version 23.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-six mutation-positive females underwent PM\/CPM (16.1%). Two (7.69%) of 26 had later post-PM recurrence. Only 8 (30.76%) patients had SLNB and all were negative. No OBC was seen in PM\/CPM specimens, whereas 3 (11.5%) had atypical ductal hyperplasia (ADH). Two of the ADH had BI-RADS-1, whereas 1 was BI-RADS-4 (33.3%) on the preoperative assessment. Results also showed that with an increase in the tumour grade of the diseased breast, the BI-RADS score of the asymptomatic breast was subsequently increased ( P\u2009=\u2009.029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study shows negative OBCs in PM\/CPM cases with persistently negative SLNB results; however, ADH is identified in 11.5% of specimens. Our results suggest that SLNB can be safely omitted in patients undergoing CPM, but, preoperatively, patient and disease factors should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11782234241311018","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T06:06:36Z","timestamp":1735797996000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Occult Breast Cancer in High-Risk Gene-Positive Pakistani Women Undergoing Contralateral Prophylactic Mastectomy\/Prophylactic Mastectomy: Implications for Sentinel Lymph Node Biopsy"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6386-4047","authenticated-orcid":false,"given":"Mehwish","family":"Mooghal","sequence":"first","affiliation":[{"name":"Section of Breast Surgery, Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wajiha","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-5204","authenticated-orcid":false,"given":"Saba","family":"Anjum","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safna Naozer","family":"Virji","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna M","family":"Vohra","sequence":"additional","affiliation":[{"name":"Section of Breast Surgery, Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"bibr1-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1186\/s13053-022-00232-2"},{"key":"bibr2-11782234241311018","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.21635"},{"key":"bibr3-11782234241311018","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0001"},{"key":"bibr4-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5925-0"},{"key":"bibr5-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11916-3"},{"key":"bibr6-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02859"},{"key":"bibr7-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.01.020"},{"key":"bibr8-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1002\/hpm.3630"},{"key":"bibr9-11782234241311018","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0051"},{"key":"bibr10-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2014.02.008"},{"key":"bibr11-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(01)00017-3"},{"key":"bibr12-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2836"},{"key":"bibr13-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1867"},{"key":"bibr14-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1447545"},{"key":"bibr15-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06410-5"},{"key":"bibr16-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.03.011"},{"key":"bibr17-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-018-04897-6"},{"key":"bibr18-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1007\/s40487-022-00202-7"},{"key":"bibr19-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00640"},{"key":"bibr20-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.142"},{"key":"bibr21-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4953-1"},{"key":"bibr22-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01319.x"},{"key":"bibr23-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2012.12.001"},{"key":"bibr24-11782234241311018","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2022.29.4.7"},{"key":"bibr25-11782234241311018","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33506"},{"key":"bibr26-11782234241311018","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.21.27022"}],"container-title":["Breast 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