{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:22:36Z","timestamp":1777454556708,"version":"3.51.4"},"reference-count":67,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Breast Cancer\ufffd(Auckl)"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Variants of the matrix metalloproteinase (MMP) gene have been associated with multiple malignancies, including stomach, bladder, lung, breast, melanoma, squamous cell skin, and colorectal cancers. Genetic factors often slightly to moderately increase the risk of breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      This study was conducted to ascertain the correlation between breast cancer patients in Bangladesh and the\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      rs243865 and\n                      <jats:italic toggle=\"yes\">MMP8<\/jats:italic>\n                      rs11225395 polymorphisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A case-control study<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS-PCR) was used for genotyping of 324 healthy individuals and 315 individuals with breast cancer. In addition, we performed in silico expression analysis of\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">MMP8<\/jats:italic>\n                      genes using different databases, such as GEPIA, UALCAN, and GTEx.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the case of\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      rs243865 polymorphism, additive model 1 (OR\u2009=\u20091.90, 95% CI\u2009=\u20091.03-3.52), dominant model (OR\u2009=\u20092.07, 95% CI\u2009=\u20091.15-3.72), overdominant model (OR\u2009=\u20091.83, 95% CI\u2009=\u20090.99-3.38), and allelic (OR\u2009=\u20091.93, 95% CI\u2009=\u20091.17-3.17) model were significantly associated with enhanced breast cancer risk. For the\n                      <jats:italic toggle=\"yes\">MMP8<\/jats:italic>\n                      rs11225395 polymorphism, none of the genetic models showed a significant association with increased breast cancer risk. The logistic regression analyses were adjusted for response status (age, BMI, and marital status). In silico analysis showed that\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      was more highly expressed in normal tissues, whereas\n                      <jats:italic toggle=\"yes\">MMP8<\/jats:italic>\n                      was more highly expressed in breast tissues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our findings imply that\n                      <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                      (rs243865) polymorphisms correlate with higher breast carcinoma risk but have no relationship with\n                      <jats:italic toggle=\"yes\">MMP8<\/jats:italic>\n                      (rs11225395) polymorphisms in the Bangladeshi female population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11782234251392714","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:36:52Z","timestamp":1763987812000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["MMP2 rs243865 and MMP8 rs11225395 Gene Polymorphisms Are Correlated With Breast Cancer Risk in Bangladeshi Women: Evidence From a Case-Control Study"],"prefix":"10.1177","volume":"19","author":[{"given":"Anamika","family":"Datta","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayma Binte","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6101-4623","authenticated-orcid":false,"given":"Khokon Kanti","family":"Bhowmik","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Abdul","family":"Barek","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Bangladesh Pharmacogenomics Research Network (BdPGRN), Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arafat","family":"Miah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Shafiul","family":"Hossen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Saddam","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4924-5319","authenticated-orcid":false,"given":"Mohammad Safiqul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Laboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh"},{"name":"Bangladesh Pharmacogenomics Research Network (BdPGRN), Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2018.05.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2021.10.946"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_3_3_5_2","first-page":"585","article-title":"A literature review of factors influencing breast cancer screening in Asian countries a literature review of factors influencing breast cancer screening in Asian countries","volume":"9","author":"Ahmadian M","year":"2012","unstructured":"Ahmadian M, Abu Samah A. A literature review of factors influencing breast cancer screening in Asian countries a literature review of factors influencing breast cancer screening in Asian countries. Life Sci J. 2012;9:585-594.","journal-title":"Life Sci J"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801289"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206300"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207951"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc745"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.05.028"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184448"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0606"},{"key":"e_1_3_3_14_2","first-page":"3987","article-title":"A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C\/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma","volume":"63","author":"Miao X","year":"2003","unstructured":"Miao X, Yu C, Tan W, et al. A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C\/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. Cancer Res. 2003;63:3987-3990.","journal-title":"Cancer Res"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9345-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1187"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0262"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-8-10"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.07.019"},{"key":"e_1_3_3_20_2","first-page":"11760","article-title":"MMP-2 and MMP-9 gene polymorphisms associated with cervical cancer risk","volume":"10","author":"Zhang H","year":"2017","unstructured":"Zhang H, Li G, Zhang Z, Wang S, Zhang S. MMP-2 and MMP-9 gene polymorphisms associated with cervical cancer risk. Int J Clin Exp Pathol. 2017;10:11760-11765.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2189"},{"key":"e_1_3_3_22_2","article-title":"The impact of matrix metalloproteinase 2 on prognosis and clinicopathology of breast cancer patients: a systematic meta-analysis","volume":"10","author":"Chen Y","year":"2015","unstructured":"Chen Y, Wang X, Chen G, Dong C, Zhang D. The impact of matrix metalloproteinase 2 on prognosis and clinicopathology of breast cancer patients: a systematic meta-analysis. PLoS ONE. 2015;10:e0121404.","journal-title":"PLoS ONE"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2014.1608"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3173-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-015-0369-y"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5269"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666150914114455"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmv124"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.2325\/jbcs.13.272"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1061"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:HIJO.0000045943.26251.24"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0637"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050442"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601725"},{"key":"e_1_3_3_35_2","first-page":"1313","article-title":"Association between matrix metalloproteinase 2 (MMP2) promoter polymorphisms and the susceptibility to non-Hodgkin\u2019s lymphoma in Egyptians","volume":"93","author":"Gouda HM","year":"2014","unstructured":"Gouda HM, Khorshied MM, El Sissy MH, Shaheen IA, Mohsen MM. Association between matrix metalloproteinase 2 (MMP2) promoter polymorphisms and the susceptibility to non-Hodgkin\u2019s lymphoma in Egyptians. Ann Hematol. 2014;93:1313-1318.","journal-title":"Ann Hematol"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1159\/000108282"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9273-1"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh020"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.22317\/jcms.v6i6.891"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2013_2000"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-3023-5"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.04.001"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.12.2731.2731"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1078"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2047"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2704-2"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3283485fdd"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1683"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1174-6"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.249"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31664-3"},{"key":"e_1_3_3_52_2","first-page":"2181","article-title":"The association of matrix metalloproteinase-8 promoter genotypes in breast cancer","volume":"38","author":"Hsiao CL","year":"2018","unstructured":"Hsiao CL, Liu LC, Shih TC, et al. The association of matrix metalloproteinase-8 promoter genotypes in breast cancer. Anticancer Res. 2018;38:2181-2185.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom9100570"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10081891"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1177\/1178223417752677"},{"key":"e_1_3_3_57_2","first-page":"1","article-title":"Are global breast cancer incidence and mortality patterns related to country-specific economic development and prevention strategies?","volume":"4","author":"Bellanger M","year":"2018","unstructured":"Bellanger M, Zeinomar N, Tehranifar P, Terry MB. Are global breast cancer incidence and mortality patterns related to country-specific economic development and prevention strategies? J Glob Oncol. 2018;4:1-16.","journal-title":"J Glob Oncol"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv022"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12230"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07919.x"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14351"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010242200"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-77"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.12.017"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0125"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.05.002"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx247"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"}],"container-title":["Breast Cancer: Basic and Clinical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11782234251392714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11782234251392714","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11782234251392714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:56:50Z","timestamp":1777381010000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11782234251392714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":67,"alternative-id":["10.1177\/11782234251392714"],"URL":"https:\/\/doi.org\/10.1177\/11782234251392714","relation":{},"ISSN":["1178-2234","1178-2234"],"issn-type":[{"value":"1178-2234","type":"print"},{"value":"1178-2234","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"article-number":"11782234251392714"}}