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The review synthesizes findings from various studies that highlight the impact of contaminants such as pesticides, heavy metals, polycyclic aromatic hydrocarbons (PAHs), microplastics, and parabens on gastrointestinal health. Following PRISMA guidelines, a comprehensive literature search across databases including PubMed, Scopus, and Google Scholar yielded 496 articles, of which 11 met the inclusion criteria for detailed analysis. The results indicate a significant correlation between exposure to specific pollutants\u2014particularly pesticides like dichlorodiphenyltrichloroethane (DDT), PAHs, arsenic, cadmium, and microplastics\u2014and increased incidences of diarrhea. Notably, studies revealed that prenatal exposure to DDT is linked to higher diarrhea rates among boys in urban settings, while pesticide exposure in childhood correlates with inflammatory bowel disease in adulthood. Mechanistically, these pollutants may disrupt gastrointestinal function through cholinergic effects and endocrine disruption, leading to altered gut motility and microbiome imbalances. Moreover, the review emphasizes the immunosuppressive effects of heavy metals such as mercury and cadmium, which compromise the immune response and increase susceptibility to gastrointestinal infections. Despite the identified associations, there is a notable gap in research regarding geographic distribution and pollutant impacts on health outcomes. The review underscores the necessity for public health interventions aimed at reducing exposure to these environmental pollutants to mitigate their adverse health effects. In conclusion, this systematic review highlights the urgent need for further epidemiological studies in underrepresented areas to enhance our understanding of how environmental pollutants influence public health globally. Recommendations include rigorous monitoring of pollutant levels, public health initiatives to reduce exposure, and policies that restrict emissions of harmful substances. Addressing environmental pollution is crucial for mitigating diarrheal diseases and protecting vulnerable populations from its detrimental effects.<\/jats:p>","DOI":"10.1177\/11786302241304539","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T07:07:32Z","timestamp":1732950452000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Exposure to Environmental Pollutants and Risk of Diarrhea: A Systematic Review"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-0882","authenticated-orcid":false,"given":"Eudora","family":"Nwanaforo","sequence":"first","affiliation":[{"name":"Department of Environmental Health Science, School of Health Technology, Federal University of Technology, Owerri, Imo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia N","family":"Obasi","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology & Toxicology, Faculty of Pharmacy, University of Port-Harcourt, Port-Harcourt, Rivers State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Frazzoli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Endocrine-Metabolic Diseases, and Ageing, Istituto Superiore di Sanit\u00e0 (Italian National Institute of Health), Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onyinyechi","family":"Bede-Ojimadu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, School of Allied Health Sciences, Kampala International University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orish E","family":"Orisakwe","sequence":"additional","affiliation":[{"name":"African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, Choba, Nigeria"},{"name":"Advanced Research Centre, European University of Lefke, Lefke, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"bibr1-11786302241304539","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpe.2015.03.011"},{"key":"bibr2-11786302241304539","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15010016"},{"key":"bibr3-11786302241304539","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3262-09.2010"},{"key":"bibr4-11786302241304539","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.312"},{"key":"bibr5-11786302241304539","doi-asserted-by":"publisher","DOI":"10.1596\/978-1-4648-0348-2_ch9"},{"key":"bibr6-11786302241304539","unstructured":"World Health Organization. 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