{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:18:46Z","timestamp":1790849926128,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Environ\ufffdHealth\ufffdInsights"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Bisphenol A (BPA) is a synthetic organic compound commonly utilized in the manufacturing of polycarbonate plastics and epoxy resins. Its widespread presence in everyday items, including water bottles, food containers, and thermal paper, has raised considerable health concerns due to its potential as an endocrine disruptor. BPA has the ability to mimic estrogen and bind to estrogen receptors, which can lead to disruptions in hormonal signaling pathways. This interference poses risks to reproductive health, especially among younger individuals, as it may result in irregular menstrual cycles, ovulation issues, and compromised spermatogenesis. Research indicates that BPA exposure can adversely affect ovarian function, diminish sperm quality, and induce oxidative stress and inflammation, further compromising fertility. The potential for BPA to cause long-term health effects through epigenetic modifications, alongside its prevalence in food contact materials, underscores the urgent need for strategies to minimize exposure. Recommended approaches include the use of BPA-free products, choosing fresh foods over canned items, and advocating for stricter regulations. A deeper understanding of the mechanisms underlying BPA\u2019s reproductive toxicity is essential for developing effective interventions. Additionally, research is needed to address critical gaps in knowledge regarding the cumulative effects of low-dose exposure, transgenerational impacts, and the specific effects on male fertility. Investigating epigenetic mechanisms, variability in susceptibility, and the safety of BPA alternatives is paramount. Furthermore, exploring effective interventions, increasing public awareness, and implementing regulatory measures are crucial steps in mitigating BPA\u2019s adverse effects on reproductive health.<\/jats:p>","DOI":"10.1177\/11786302251330774","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T06:40:52Z","timestamp":1751092852000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["The Silent Threat of BPA: Its Pervasive Presence and Impact on Reproductive Health"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-6854","authenticated-orcid":false,"given":"Sanman","family":"Samova","sequence":"first","affiliation":[{"name":"Gujarat Biotechnology Research Centre, Gandhinagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-6348","authenticated-orcid":false,"given":"Hetal","family":"Doctor","sequence":"additional","affiliation":[{"name":"President Science College, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2008.159228"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2011.05.002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2012.03.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3936-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.07.059"},{"key":"e_1_3_2_7_2","first-page":"14","article-title":"Bisphenol A: product profile","volume":"17","author":"Burridge E.","year":"2003","unstructured":"Burridge E. 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