{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:15:14Z","timestamp":1777673714345,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health&amp;#65533;Serv&amp;#65533;Insights"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Stroke is a leading cause of long-term disability, significantly impacting health-related quality of life (HRQoL). However, evidence from Nepal remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to assess HRQoL and identify its associated factors among stroke patients in a tertiary care hospital in Nepal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional study<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This study was conducted at the Annapurna Neurological Institute and Allied Sciences (ANIAS) between November 2023 and April 2024 among 120 stroke patients aged \u2a7e18\u2009years. Baseline data were collected using a semi-structured questionnaire, and HRQoL was assessed using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) scale. Statistical analyses included descriptive statistics, bivariate analyses, and multiple linear regression to identify factors associated with HRQoL. A\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009&lt;\u2009.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean HRQoL score was 21.13\u2009\u00b1\u20096.62, indicating substantial impairment, particularly in usual activities (Mean\u2009\u00b1\u2009SD: 4.32\u2009\u00b1\u20091.32), self-care (4.26\u2009\u00b1\u20091.34), and mobility (4.22\u2009\u00b1\u20091.32). Lower HRQoL was significantly associated with older age, unemployment, lower educational attainment, and moderate to severe stroke-related disability (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u2009.001). Strong positive correlations were observed among all five HRQoL domains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>HRQoL is significantly impacted by stroke, with major impairments in usual activities, self-care, and mobility, influenced by both socio-demographic and clinical factors. Implementing targeted, multidimensional rehabilitation strategies such as structured physiotherapy is essential to enhance recovery and improve the quality of life in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11786329251378546","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T09:32:42Z","timestamp":1759051962000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Health-Related Quality of Life and Associated Factors Among Patients with Stroke at Tertiary Care Hospital Nepal"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-382X","authenticated-orcid":false,"given":"Nirmal Raj","family":"Marasine","sequence":"first","affiliation":[{"name":"Department of Pharmacy, CiST College, Baneshwor, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saru","family":"Panthi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, CiST College, Baneshwor, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Sankhi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shree College of Technology, Bharatpur, Chitwan, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02446-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0311325"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"issue":"3","key":"e_1_3_3_5_2","article-title":"Heart disease and stroke statistics\u20142014 update: a report from the American Heart Association","volume":"129","author":"Go AS","year":"2014","unstructured":"Go AS, Mozaffarian D, Roger VL, et al Heart disease and stroke statistics\u20142014 update: a report from the American Heart Association. 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