{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:39:26Z","timestamp":1778031566015,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Infect Dis (Auckl)"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Influenza causes significant morbidity and mortality in adults, and numerous patients require intensive care unit (ICU) admission. Acute respiratory distress syndrome (ARDS) is clearly described in this context, but other clinical presentations exist that need to be assessed for incidence and outcome. The primary goal of this study was to describe the characteristics of patients admitted in ICU for influenza, their clinical presentation, and the 3-month mortality rate. The second objective was to search for 3-month mortality risk factors. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> This is a retrospective study including all patients admitted to 3 ICUs due to influenza-related disease between October 2013 and June 2016, which assesses the 3-month mortality rate. We compared clinical presentation, biological data, and outcome at 3\u2009months between survivors and non-survivors. We created a predicting 3-month mortality model with Classification and Regression Tree analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Sixty-nine patients were included, 50 patients (72.5%) for ARDS, 5 (7.2%) for myocarditis, and 14 (20.3%) for acute respiratory failure without ARDS criteria. Non-typed influenza A was found in 30 cases (43.5%), influenza A H1N1 in 18 (26.1%), H3N2 in 3 (4.3%), and influenza B in 18 cases (27.5%). The 3-month mortality rate was 29% ( n\u2009=\u200920). Extracorporeal membrane oxygenation (ECMO) was implanted in 23 patients, without any significant increase in mortality (39% vs 24% without ECMO, P\u2009=\u2009.19). A creatinine serum superior to 96\u2009\u03bcmol\/L, an aspartate aminotransferase level superior to 68\u2009UI\/L, and a Pao<jats:sub>2<\/jats:sub>\/Fio<jats:sub>2<\/jats:sub> ration below 110 were associated with 3-month mortality in our predictive mortality model. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Influenza in ICUs may have several clinical presentations. The mortality rate is high, but ECMO may be an effective rescue therapy. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1178633720904081","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T11:30:51Z","timestamp":1580988651000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcome of Critically Ill Patients With Influenza Infection: A Retrospective Study"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-3441","authenticated-orcid":false,"given":"Timoth\u00e9e","family":"Abaziou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-9128","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Delmas","sequence":"additional","affiliation":[{"name":"Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Vardon Bounes","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Bignon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Joseph Ducuing Hospital, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Crognier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Seguin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Riu-Poulenc","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Rouget","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Cougot","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Georges","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marie","family":"Conil","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Minville","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"bibr1-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12267."},{"key":"bibr2-1178633720904081","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00320."},{"key":"bibr3-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1496."},{"key":"bibr4-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908481."},{"key":"bibr5-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx212."},{"key":"bibr6-1178633720904081","doi-asserted-by":"crossref","first-page":"20139","DOI":"10.2807\/ese.17.14.20139-en","volume":"17","author":"Mytton OT","year":"2012","journal-title":"Euro Surveill"},{"key":"bibr7-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000545."},{"key":"bibr8-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201401-0066LE."},{"key":"bibr9-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165711."},{"key":"bibr10-1178633720904081","unstructured":"World Health Organization. Human infection with influenza A(H7N9) virus in China. http:\/\/www.who.int\/csr\/don\/2013_04_01\/en\/index.html. Accessed September 5, 2013."},{"key":"bibr11-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000262940.34596.4B."},{"key":"bibr12-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1004-y"},{"key":"bibr13-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12470."},{"key":"bibr14-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2344."},{"key":"bibr15-1178633720904081","first-page":"654","volume":"75","author":"De Rosa FG","year":"2009","journal-title":"Minerva Anestesiol"},{"key":"bibr16-1178633720904081","unstructured":"ELSO Guidelines for Cardiopulmonary Extracorporeal Life Support Extracorporeal Life Support Organization, Version 1.4. Ann Arbor, MI: ELSO; 2017."},{"key":"bibr17-1178633720904081","unstructured":"H1N1 Specific Supplements to the ELSO General Guidelines Extracorporeal Life Support Organization, Version 1.4. Ann Arbor, MI: ELSO; 2017."},{"key":"bibr18-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669."},{"key":"bibr19-1178633720904081","volume-title":"Classification and Regression Trees","author":"Breiman L","year":"1998"},{"key":"bibr20-1178633720904081","doi-asserted-by":"publisher","DOI":"10.2807\/ese.15.02.19463-en"},{"key":"bibr21-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70121-4."},{"key":"bibr22-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-869."},{"key":"bibr23-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1164\/201001-0037OC."},{"key":"bibr24-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61069-2."},{"key":"bibr25-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800385."},{"key":"bibr26-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1471."},{"key":"bibr27-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0815OC."},{"key":"bibr28-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1568-y."},{"key":"bibr29-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2747-1."},{"key":"bibr30-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5828."},{"key":"bibr31-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-123."},{"key":"bibr32-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2166-8."},{"key":"bibr33-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192592."},{"key":"bibr34-1178633720904081","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2018901."},{"key":"bibr35-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305584."},{"key":"bibr36-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-2659.2011.00287.x."},{"key":"bibr37-1178633720904081","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4141-2."}],"container-title":["Infectious Diseases: Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1178633720904081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1178633720904081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1178633720904081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T15:54:00Z","timestamp":1729094040000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1178633720904081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":37,"alternative-id":["10.1177\/1178633720904081"],"URL":"https:\/\/doi.org\/10.1177\/1178633720904081","relation":{},"ISSN":["1178-6337","1178-6337"],"issn-type":[{"value":"1178-6337","type":"print"},{"value":"1178-6337","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1178633720904081"}}