{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:42:54Z","timestamp":1791290574159,"version":"4.3.0"},"reference-count":68,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbiol\ufffdInsights"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To perform systematic review and meta-analysis of meningococcal disease burden in India. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of Meningococcal meningitis and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The prevalence of Meningococcal meningitis in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; N. meningitis caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks. <\/jats:p><\/jats:sec>","DOI":"10.1177\/11786361211053344","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T09:29:38Z","timestamp":1638178178000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-3209","authenticated-orcid":false,"given":"Canna Jagdish","family":"Ghia","sequence":"first","affiliation":[{"name":"Medical and Scientific Affairs, Pfizer Limited, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam Sudhakar","family":"Rambhad","sequence":"additional","affiliation":[{"name":"Medical and Scientific Affairs, Pfizer Limited, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"bibr1-11786361211053344","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-1237(05)80071-1"},{"key":"bibr2-11786361211053344","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.10.022"},{"key":"bibr3-11786361211053344","unstructured":"World Health Organization. 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