{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:01:16Z","timestamp":1787497276480,"version":"build-2736575974"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Metab Insights"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Any alteration in nutritional status can compromise the progression of breast cancer, as well as the tolerance and efficacy of chemotherapy. The aims of our study were to assess the nutritional status of breast cancer patients treated with chemotherapy and to identify nutritional factors that may exacerbate chemo-induced digestive toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This descriptive cross-sectional study was conducted within the medical oncology department of the National Institute of Salah Azaiez. A Mediterranean Diet Score (MDS) was used to evaluate the level of adherence to the Mediterranean Diet. Nutritional status was assessed using 2 methods; body composition evaluation utilising the TANITA BC 601 impedance metre and High authority of health (HAS) criteria of malnutrition. Digestive effects were assessed with World Health Organization (WHO) grades ranging from 0 to 4. High grades 3 and 4 signified toxic grades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We enrolled 107 adult women diagnosed with breast cancer undergoing the same chemotherapy protocol. The participants had an average age of 52.56\u2009\u00b1\u20099.75\u2009years and an average BMI of 29.85\u2009\u00b1\u20095.72\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      with 78.5% classified as overweight. Malnutrition was observed in 41% of patients, while sarcopenia was present in 12%. Chemotherapy-related adverse effects were predominantly constipation (80%), diarrhea (73%), nausea (70%) and vomiting (63.4%) with one-third experiencing high-grade toxicity. Strong adherence to Mediterranean Diet was observed in 48.6% of cases and higher MDS scores were inversely correlated with the severity of nausea ( P\u2009=\u2009.01) and constipation ( P\u2009=\u2009.02). Malnutrition was significantly associated with all digestive toxicities except with constipation. Sarcopenia was associated only with vomiting ( P\u2009=\u2009.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a relationship between nutritional status and digestive toxicity, justifying early nutritional treatment to improve the tolerance and efficacy of chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11786388241297142","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:56:11Z","timestamp":1732064171000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Nutritional Status on Chemotherapy Related Digestive Toxicity in Women With Breast Cancer"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-7922","authenticated-orcid":false,"given":"Berriche","family":"Olfa","sequence":"first","affiliation":[{"name":"University of Tunis El Manar Faculty of Medicine of Tunis, Tunis, Tunisia"},{"name":"National Institute of Nutrition and Food Technology, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Salma","sequence":"additional","affiliation":[{"name":"National Institute of Nutrition and Food Technology, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Othman Rym","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar Faculty of Medicine of Tunis, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Mansour Hajer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology of the National Institute of Salah Azaiez, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khiari","family":"Houyem","sequence":"additional","affiliation":[{"name":"Department of Community and Preventive Medicine of the National Institute of Salah Azaiez, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamoussi","family":"Henda","sequence":"additional","affiliation":[{"name":"National Institute of Nutrition and Food Technology, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mezlini","family":"Amel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology of the National Institute of Salah Azaiez, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"bibr1-11786388241297142","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"bibr2-11786388241297142","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2021.03.001"},{"key":"bibr3-11786388241297142","doi-asserted-by":"publisher","DOI":"10.1016\/S1773-035X(14)72711-X"},{"key":"bibr4-11786388241297142","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2016.04.002"},{"key":"bibr5-11786388241297142","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-023-02585-9"},{"key":"bibr6-11786388241297142","unstructured":"Gallois C, Li\u00e8vre A, Bourillon C et al. Risque nutritionnel et tol\u00e9rance de la chimioth\u00e9rapie chez les patients atteints de cancer colorectal m\u00e9tastatique : r\u00e9sultats d\u2019une \u00e9tude multicentrique prospective de l\u2019AGEO. Comptes Rendus des Journ\u00e9es Francophones d\u2019H\u00e9pato-gastroent\u00e9rologie et d\u2019Oncologie Digestive, Paris, 22-25 March 2018."},{"key":"bibr7-11786388241297142","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1870703"},{"key":"bibr8-11786388241297142","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.20.25223"},{"key":"bibr9-11786388241297142","volume-title":"Registre des cancers: donn\u00e9es 2010-2014","author":"Hsairi M","year":"2021"},{"key":"bibr10-11786388241297142","unstructured":"Institut National du Cancer. Traitements locor\u00e9gionaux des cancers du sein infiltrants non m\u00e9tastatiques. Th\u00e9saurus partie 1, collection Recommandations et r\u00e9f\u00e9rentiels. 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