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Recent evidence suggests that anti-inflammatory agents may reduce the risk of depression. The present study aimed to elucidate the potential of the citrus flavonoid hesperidin, which exhibits anti-inflammatory activity, in suppressing the Trp-Kyn pathway in the brain, using a lipopolysaccharide (LPS)-induced inflammation mouse model. Dietary hesperidin was found to suppress activation of the Trp-Kyn pathway in the prefrontal cortex. In addition, it reduced systemic LPS-induced signs of illness, such as low skin temperature and enhanced leukocyte count in the blood. However, dietary supplementation with hesperidin did not improve body weight loss, food intake, water intake, or splenic increases in leukocyte numbers in the LPS model. Collectively, the results suggest that dietary hesperidin can partially regulate central and peripheral events linked to inflammation in LPS mouse models.<\/jats:p>","DOI":"10.1177\/11786469221128697","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T04:51:43Z","timestamp":1666932703000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Dietary Hesperidin Suppresses Lipopolysaccharide-Induced Inflammation in Male Mice"],"prefix":"10.1177","volume":"15","author":[{"given":"Mizuho","family":"Sato","sequence":"first","affiliation":[{"name":"College of Agriculture, Ibaraki University, Ami, Ibaraki, Japan"},{"name":"United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"},{"name":"Faculty of Human Science, Tokiwa University, Mito, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alato","family":"Okuno","sequence":"additional","affiliation":[{"name":"Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM), Ami, Ibaraki, Japan"},{"name":"Intestinal Food Medicine Inc., Ami, Ibaraki, Japan"},{"name":"College of Life Creation, Shibata Gakuen University, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Ishisono","sequence":"additional","affiliation":[{"name":"Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM), Ami, Ibaraki, Japan"},{"name":"Bioscience Research Department, TOA Biopharma Co., Ltd. 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