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Beyond its nutritional role, tryptophan metabolism critically regulates the nervous, immune and endocrine systems, coordinates circadian rhythms via melatonin, and exerts antioxidant effects. These processes are profoundly remodeled during pregnancy. Pregnancy represents a unique physiological state characterized by systemic adaptations, including changes in immunity and erythropoiesis, while the placenta emerges as a central organ coordinating fetal development, maternal\u2013fetal exchanges, immune tolerance, and protection against external infections. Increasing evidence indicates that tryptophan availability and its downstream metabolites play key roles in maintaining maternal\u2013fetal and placental homeostasis. In particular, serotonin, traditionally viewed as a neurotransmitter, has emerged as a locally produced signaling molecule in the placenta, impacting trophoblast development, placental vascularization, and immune modulation. Dysregulation of tryptophan metabolic pathways has been associated with pregnancy complications and adverse developmental outcomes. This review aims to provide an overview of tryptophan metabolism during gestation, with a specific focus on serotonin as a key factor in placental homeostasis. Targeting tryptophan-derived pathways may offer novel opportunities to improve maternal and neonatal health.<\/jats:p>","DOI":"10.1177\/11786469261449491","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:27:42Z","timestamp":1778239662000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Tryptophan\u2019s Journey Through Pregnancy: The Role of Serotonin"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6961-5096","authenticated-orcid":false,"given":"Beno\u00eet","family":"Gendrot","sequence":"first","affiliation":[{"name":"Institut Cochin, INSERM U1016, CNRS UMR8104, Universit\u00e9 de Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-6244","authenticated-orcid":false,"given":"Cathy","family":"Vaillancourt","sequence":"additional","affiliation":[{"name":"Institut 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