{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:14:25Z","timestamp":1783336465354,"version":"3.54.6"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"CPER R\u00e9gion Hauts de France"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J&amp;#65533;Tryptophan&amp;#65533;Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    The kynurenine pathway (KP) has been implicated in a broad range of neurological disorders. KP activation in brain resident immune cells, including astrocytes and microglia, contributes to the release of neuroactive metabolites with strong impact on neuronal functions. KP activation is triggered by inflammatory cues, however the contribution of chronic brain infections on KP activation remains poorly explored. Toxoplasmosis is 1 of the most common infections caused by protozoan parasites. Infection of immuno-competent individuals is characterized by bradyzoite-containing cyst development in neurons, leading to life-long chronic infections. Control of latent toxoplasmosis relies on an IL-12-induced T-cell derived IFN\u03b3 response, and results in a sustained inflammation of the brain characterized by activation of recruited and resident immune cells. Here, we investigated a possible link between induction of a persistent neuroinflammation induced by\n                    <jats:italic toggle=\"yes\">Toxoplasma gondii<\/jats:italic>\n                    long-term infection, modulation of the KP and production of key neuroactive metabolites. Our findings demonstrate that chronic infection with either of 2\n                    <jats:italic toggle=\"yes\">Toxoplasma gondii<\/jats:italic>\n                    strains\u2014 causing encephalitis and the other inducing latency\u2014leads to sustained activation of the KP, resulting in increased production of quinolinic acid, an excitotoxic metabolite known to have detrimental effects on neurons.\n                  <\/jats:p>","DOI":"10.1177\/11786469261461119","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:37:42Z","timestamp":1783067862000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Latent Cerebral Toxoplasma Gondii Infection Induces the Kynurenine Pathway and Production of Neurotoxic Metabolites"],"prefix":"10.1177","volume":"19","author":[{"given":"Amir Mohamed","family":"Kezai","sequence":"first","affiliation":[{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL- Center for Infection &amp; Immunity of Lille, France"},{"name":"CHU de Qu\u00e9bec Research Center, Qu\u00e9bec City, Canada"},{"name":"Department of Psychiatry and Neurosciences, Laval University, Qu\u00e9bec City, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoudou","family":"Ba","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL- Center for Infection &amp; Immunity of Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hennart","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Fonctionnelle de Toxicologie, CHU Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anais","family":"Jacquemart","sequence":"additional","affiliation":[{"name":"Univ. 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