{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:16:26Z","timestamp":1773515786821,"version":"3.50.1"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J\ufffdCell Death"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Active caspase-3-mediated apoptosis has been implicated in the pathogenesis of harmaline-induced tremor. The aim of this study is to illustrate the impact of tremor induction on the expression of factors mediating the cell surface death receptor\u2013dependent apoptosis. A total of 20 normal Wistar rats were randomly selected and equally divided into control and experimental groups. Tremor was induced in the experimental group by injecting the rats with a single dose of harmaline (50\u2009mg\/kg). After that, cerebellar tissues were evaluated by immunohistochemistry to examine the expression of tumor necrosis factor \u03b1 (TNF-\u03b1) and active caspase-8 in the 2 groups of animals. TNF-\u03b1 and active caspase-8 expression was significantly higher in cerebella from experimental rats compared with that in those from the control rats (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    value\u2009&lt;\u2009.01). Thus, our present data suggest the association of tremor induction with the cerebellar overexpression of TNF-\u03b1 and active caspase-8, correlative with Purkinje cell (PC) loss indicated by loss of calbindin immunoreactivity, indicating the induction of the cell surface death receptor\u2013mediated apoptosis.\n                  <\/jats:p>","DOI":"10.1177\/1179066018809091","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T04:45:07Z","timestamp":1541393107000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Cerebellar Upregulation of Cell Surface Death Receptor\u2013Mediated Apoptotic Factors in Harmaline-Induced Tremor: An Immunohistochemistry Study"],"prefix":"10.1177","volume":"11","author":[{"given":"Nour S","family":"Erekat","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afj072."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.08.017."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.06.023"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7916\/D8TD9W2P."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.11.036."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90500-F"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90102-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/01913123.2018.1424744."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.12.025."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701320337."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-3229-6_4."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008672."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.04789804."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.64.4.821-846.2000"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400601."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008656."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400599."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23124."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.05.015."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00003-9"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(98)00109-1"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26471."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.130105."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.14740\/cr314w."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-172196."},{"key":"e_1_3_2_27_2","first-page":"108","article-title":"Endurance exercise training attenuates the up regulation of iNOS in the skeletal muscles of chronic\/progressive mouse model of Parkinson\u2019s disease","volume":"3","author":"Erekat N","year":"2013","unstructured":"Erekat N, Al Khatib A, Al-Jarrah M. 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