{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:15:46Z","timestamp":1777605346090,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Exp Neurosci"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>The neurobiological contributions to anorexia nervosa (AN) remain poorly understood, hindering the development of effective neurobiological treatments such as medications and brain stimulation. A large number of studies have been undertaken utilising neuroimaging techniques, such as magnetic resonance imaging (MRI), to gain a better understanding of the brain mechanisms involved in the illness. However, the analyses undertaken by many studies have utilised a whole-brain analytical approach as much of this research has been exploratory in nature. This is, however, problematic as small brain regions that differ between groups may not have the statistical power to produce statistically significant results. This is highlighted in a recent study undertaken by our group utilising diffusion-weighted imaging. In this research, we identified widespread white matter microstructural differences in individuals with AN, but only showed differences in a small brain region (the superior colliculus) when a region-of-interest approach that was driven by behavioural findings was utilised. The importance of hypothesis-driven neuroimaging analyses is discussed in this article.<\/jats:p>","DOI":"10.1177\/1179069518820068","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T03:54:09Z","timestamp":1545278049000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["An Overlooked Brain Region in the Aetiology of Anorexia Nervosa: The Importance of Behaviourally Driven Neuroimaging Analysis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-6619","authenticated-orcid":false,"given":"Andrea","family":"Phillipou","sequence":"first","affiliation":[{"name":"Centre for Mental Health, Swinburne University of Technology, Hawthorn, VIC, Australia"},{"name":"Department of Mental Health, St Vincent\u2019s Hospital, Melbourne, Melbourne, VIC, Australia"},{"name":"Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia"},{"name":"Department of Mental Health, Austin Health, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Jonathan","family":"Castle","sequence":"additional","affiliation":[{"name":"Department of Mental Health, St Vincent\u2019s Hospital, Melbourne, Melbourne, VIC, Australia"},{"name":"Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry Allen","family":"Abel","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Gurvich","sequence":"additional","affiliation":[{"name":"Monash Alfred Psychiatry Research Centre, Monash University and The Alfred Hospital, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan Lee","family":"Rossell","sequence":"additional","affiliation":[{"name":"Centre for Mental Health, Swinburne University of Technology, Hawthorn, VIC, Australia"},{"name":"Department of Mental Health, St Vincent\u2019s Hospital, Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,20]]},"reference":[{"key":"bibr1-1179069518820068","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.173.1.11"},{"key":"bibr2-1179069518820068","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.7.1073"},{"key":"bibr3-1179069518820068","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20309"},{"key":"bibr4-1179069518820068","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.8.1284"},{"key":"bibr5-1179069518820068","unstructured":"Deloitte Access Economics. Paying the price: the economic and social impact of eating disorders in Australia. https:\/\/researchdirect.westernsydney.edu.au\/islandora\/object\/uws:23220. 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