{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:10:57Z","timestamp":1790745057978,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Exp Neurosci"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>A hallmark of many neuromuscular diseases including Alzheimer disease, inclusion body myositis, amyotrophic lateral sclerosis, frontotemporal lobar dementia, and ocular pharyngeal muscular dystrophy is large cytoplasmic aggregates containing the RNA-binding protein, TDP-43. Despite acceptance that cytoplasmic TDP-43 aggregation is pathological, cytoplasmic TDP-43 assemblies form in healthy regenerating muscle. These recently discovered ribonucleoprotein assemblies, termed myo-granules, form in healthy muscle following injury and are readily cleared as the myofibers mature. The formation and dissolution of myo-granules during normal muscle regeneration suggests that these amyloid-like oligomers may be functional and that perturbations in myo-granule kinetics or composition may promote pathological aggregation.<\/jats:p>","DOI":"10.1177\/1179069519842157","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T04:25:13Z","timestamp":1555043113000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Myo-granules Connect Physiology and Pathophysiology"],"prefix":"10.1177","volume":"13","author":[{"given":"Alicia A","family":"Cutler","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore Eugene","family":"Ewachiw","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia A","family":"Corbet","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad B","family":"Olwin","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"bibr1-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0665-2."},{"key":"bibr2-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjy025"},{"key":"bibr3-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.044222"},{"key":"bibr4-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/712315."},{"key":"bibr5-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baw153"},{"key":"bibr6-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.15.6167"},{"key":"bibr7-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20370"},{"key":"bibr8-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.07.077"},{"key":"bibr9-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-24-07812.1996"},{"key":"bibr10-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.01.012"},{"key":"bibr11-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.299"},{"key":"bibr12-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000041631.28557.C6"},{"key":"bibr13-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-164"},{"key":"bibr14-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0528-y"},{"key":"bibr15-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001862"},{"key":"bibr16-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.015"},{"key":"bibr17-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200908115"},{"key":"bibr18-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.093"},{"key":"bibr19-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24388"},{"key":"bibr20-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"bibr21-1179069519842157","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.10.021"}],"container-title":["Journal of Experimental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179069519842157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1179069519842157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179069519842157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:03:27Z","timestamp":1777410207000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1179069519842157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":21,"alternative-id":["10.1177\/1179069519842157"],"URL":"https:\/\/doi.org\/10.1177\/1179069519842157","relation":{},"ISSN":["1179-0695","1179-0695"],"issn-type":[{"value":"1179-0695","type":"print"},{"value":"1179-0695","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"1179069519842157"}}