{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:30:20Z","timestamp":1790213420829,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["PUP program"],"award-info":[{"award-number":["PUP program"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR001072"],"award-info":[{"award-number":["TL1TR001072"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS082432"],"award-info":[{"award-number":["R01 NS082432"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Exp Neurosci"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Mild traumatic brain injury (mTBI), also known as concussion, is a serious public health challenge. Although most patients recover, a substantial minority suffers chronic disability. The mechanisms underlying mTBI-related detrimental effects remain poorly understood. Although animal models contribute valuable preclinical information and improve our understanding of the underlying mechanisms following mTBI, only few studies have used diffusion tensor imaging (DTI) to study the evolution of axonal injury following mTBI in rodents. It is known that DTI shows changes after human concussion and the role of delineating imaging findings in animals is therefore to facilitate understanding of related mechanisms. In this work, we used a rodent model of mTBI to investigate longitudinal indices of axonal injury. We present the results of 45 animals that received magnetic resonance imaging (MRI) at multiple time points over a 2-week period following concussive or sham injury yielding 109 serial observations. Overall, the evolution of DTI metrics following concussive or sham injury differed by group. Diffusion tensor imaging changes within the white matter were most noticeable 1\u2009week following injury and returned to baseline values after 2\u2009weeks. More specifically, we observed increased fractional anisotropy in combination with decreased radial diffusivity and mean diffusivity, in the absence of changes in axial diffusivity, within the white matter of the genu corpus callosum at 1\u2009week post-injury. Our study shows that DTI can detect microstructural white matter changes in the absence of gross abnormalities as indicated by visual screening of anatomical MRI and hematoxylin and eosin (H&amp;E)-stained sections in a clinically relevant animal model of mTBI. Whereas additional histopathologic characterization is required to better understand the neurobiological correlates of DTI measures, our findings highlight the evolving nature of the brain\u2019s response to injury following concussion.<\/jats:p>","DOI":"10.1177\/1179069519858627","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T05:09:27Z","timestamp":1562303367000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Diffusion Tensor Imaging of the Evolving Response to Mild Traumatic Brain Injury in Rats"],"prefix":"10.1177","volume":"13","author":[{"given":"Wouter S","family":"Hoogenboom","sequence":"first","affiliation":[{"name":"The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Department of Clinical Investigation, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2821-5877","authenticated-orcid":false,"given":"Todd G","family":"Rubin","sequence":"additional","affiliation":[{"name":"The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hui","family":"Cui","sequence":"additional","affiliation":[{"name":"The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey C","family":"Branch","sequence":"additional","affiliation":[{"name":"The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A","family":"Branch","sequence":"additional","affiliation":[{"name":"The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Department of Physiology and Biophysics, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4702-2114","authenticated-orcid":false,"given":"Michael L","family":"Lipton","sequence":"additional","affiliation":[{"name":"The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"bibr1-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2015.03.001"},{"key":"bibr2-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9162-7"},{"key":"bibr3-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e31817579d1"},{"key":"bibr4-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004214"},{"key":"bibr5-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9156-5"},{"key":"bibr6-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80775-1"},{"key":"bibr7-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"bibr8-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21200"},{"key":"bibr9-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9175-2"},{"key":"bibr10-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.01.001"},{"key":"bibr11-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3407"},{"key":"bibr12-1179069519858627","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.09.014"},{"key":"bibr13-1179069519858627","unstructured":"Bolouri H, Zetterberg H. 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