{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:31:16Z","timestamp":1790062276804,"version":"4.0.1"},"reference-count":60,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdArthritis\ufffdMusculoskelet Disord"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientific community. It is important to understand its etiopathogenic mechanism and its functions in these diseases. Although the diagnostic and prognostic roles of HLA-B27 in AS are still debated, there is an increasing interest for HLA-B27\u2013based effects especially in HLA-B27(+) patients with AS. This review will focus in the examination of published reports regarding the influence of HLA-B27 status on the demographic and clinical features in AS, with specific interest to its role on AS severity.<\/jats:p>","DOI":"10.1177\/1179544117751627","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:21:14Z","timestamp":1515457274000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?"],"prefix":"10.1177","volume":"11","author":[{"given":"Amal","family":"Akassou","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Immunology, Faculty of Sciences, Mohammed V University Agdal, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Bakri","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Immunology, Faculty of Sciences, Mohammed V University Agdal, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"bibr1-1179544117751627","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-12-200206180-00011"},{"key":"bibr2-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199801)41:1<58::AID-ART8>3.0.CO;2-G"},{"key":"bibr3-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket387"},{"key":"bibr4-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401015"},{"key":"bibr5-1179544117751627","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oso\/9780192627490.003.0002","volume-title":"The Spondyloarthritides","author":"Khan MA.","year":"1998"},{"key":"bibr6-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304052881403"},{"key":"bibr7-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91360-3"},{"key":"bibr8-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.02.001"},{"key":"bibr9-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(90)90051-A"},{"key":"bibr10-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev218"},{"key":"bibr11-1179544117751627","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002653"},{"key":"bibr12-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1038\/329506a0"},{"key":"bibr13-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1038\/384134a0"},{"key":"bibr14-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00299-3"},{"key":"bibr15-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0640-1"},{"key":"bibr16-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.03.004"},{"key":"bibr17-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112110"},{"key":"bibr18-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31591-4"},{"key":"bibr19-1179544117751627","first-page":"770","volume":"17","author":"Slobodin G","year":"2015","journal-title":"IMAJ"},{"key":"bibr20-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.011247"},{"key":"bibr21-1179544117751627","first-page":"118","volume":"87","author":"Linssen A.","year":"1990","journal-title":"Scand J Rheumatol"},{"key":"bibr22-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.11.003"},{"key":"bibr23-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12186"},{"key":"bibr24-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-015-3342-x"},{"key":"bibr25-1179544117751627","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.4.532"},{"key":"bibr26-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.6.401"},{"key":"bibr27-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0743-0"},{"key":"bibr28-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"bibr29-1179544117751627","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2015.511"},{"key":"bibr30-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.11.883"},{"key":"bibr31-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270301"},{"key":"bibr32-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089599"},{"key":"bibr33-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21601"},{"key":"bibr34-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1002\/art.39766"},{"key":"bibr35-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200401"},{"key":"bibr36-1179544117751627","first-page":"S11","volume":"20","author":"Lautermann D","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"bibr37-1179544117751627","first-page":"22","volume":"30","author":"Xiong J","year":"2014","journal-title":"Pak J Med Sci"},{"key":"bibr38-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2009.11.015"},{"key":"bibr39-1179544117751627","first-page":"574","volume":"27","author":"Kim TJ","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"bibr40-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72165-8"},{"key":"bibr41-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041103"},{"key":"bibr42-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)99033-9"},{"key":"bibr43-1179544117751627","first-page":"689","volume":"12","author":"D\u2019Ambrosio EM","year":"2016","journal-title":"Semin Ophthalmol"},{"key":"bibr44-1179544117751627","first-page":"321","volume":"12","author":"Fallahi S","year":"2013","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"bibr45-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.8.714"},{"key":"bibr46-1179544117751627","first-page":"78","volume":"7","author":"Popescu C","year":"2014","journal-title":"J Med Life"},{"key":"bibr47-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1978.tb01280.x"},{"key":"bibr48-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.17"},{"key":"bibr49-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1002\/art.24467"},{"key":"bibr50-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1002\/art.24933"},{"key":"bibr51-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2667"},{"key":"bibr52-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1038\/ng.873"},{"key":"bibr53-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201774"},{"key":"bibr54-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137189"},{"key":"bibr55-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/594878"},{"key":"bibr56-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12254"},{"key":"bibr57-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2011.01635.x"},{"key":"bibr58-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01406.x"},{"key":"bibr59-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0602-z"},{"key":"bibr60-1179544117751627","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2009.01377.x"}],"container-title":["Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179544117751627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1179544117751627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179544117751627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:11:03Z","timestamp":1777371063000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1179544117751627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":60,"alternative-id":["10.1177\/1179544117751627"],"URL":"https:\/\/doi.org\/10.1177\/1179544117751627","relation":{},"ISSN":["1179-5441","1179-5441"],"issn-type":[{"value":"1179-5441","type":"print"},{"value":"1179-5441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"1179544117751627"}}