{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:00:28Z","timestamp":1784242828787,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdArthritis\ufffdMusculoskelet Disord"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although high serum levels of interleukin (IL)-17 and its producing cells have been found in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in earlier research, it is still unclear how these findings relate to disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study examines the link between serum levels of IL-17 and the activity of both RA and SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This pilot case\u2013control study included 100 patients with RA, 100 with SLE, and 100 healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The Disease Activity Score-28 (DAS28) scores assessed the activity of RA, whereas the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores assessed SLE activity. All participants\u2019 data were compared and correlated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Serum levels of IL-17 were significantly higher in RA and SLE patients compared with the controls ( P\u2009&lt;\u2009.001) and showed significantly positive correlations ( P\u2009&lt;\u2009.001) with rheumatoid factor titer, anti-cyclic citrullinated peptide (anti-CCP) and DAS28 score among the RA patients. Although among SLE patients, they were significantly positively correlated ( P\u2009&lt;\u2009.001) with anti-double-stranded DNA (anti-ds DNA) levels and the SLEDAI-2K scores, the best cut-off value of IL-17 for predicting moderate and high disease activity was\u2009&gt;\u2009175\u2009pg\/mL among RA patients and\u2009&gt;\u200995\u2009pg\/mL among SLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There is a significant correlation between RA and SLE activity and serum levels of IL-17. This discovery emphasizes IL-17 as a potential therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795441241276880","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T13:14:05Z","timestamp":1726578845000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of Interleukin-17 in Predicting Activity of Rheumatoid Arthritis and Systemic Lupus Erythematosus"],"prefix":"10.1177","volume":"17","author":[{"given":"Sara F","family":"Samaan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-8701","authenticated-orcid":false,"given":"Sara I","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma A","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Elsaadawy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma A","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M","family":"Gamal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"bibr1-11795441241276880","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2021.0470"},{"key":"bibr2-11795441241276880","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110496"},{"key":"bibr3-11795441241276880","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2017.16059"},{"key":"bibr4-11795441241276880","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20192048"},{"key":"bibr5-11795441241276880","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319891243"},{"key":"bibr6-11795441241276880","doi-asserted-by":"publisher","DOI":"10.1177\/2050312119876146"},{"key":"bibr7-11795441241276880","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30330"},{"key":"bibr8-11795441241276880","first-page":"5","volume":"56","author":"Fassbender 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