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We report a case of resistant RP, complicated with PPP. A 36-year-old female presented with fever, nose and earlobe chondritis, and symmetric arthritis. Infectious and connective tissue diseases were ruled out. The RP diagnosis was made, and she was treated with corticosteroids and methotrexate. Three years later, she experienced acute dyspnea due to tracheobronchial chondritis, and she was placed on induction treatment with 6 cyclophosphamide pulses, accompanied by maintenance therapy with mycophenolate mofetil (MMF). After 4 years, she presented with scleritis and panuveitis. The MMF was discontinued, and she was treated with tocilizumab (TCZ) 162\u2009mg\/week. Four months after the initiation of TCZ, the patient experienced erythematous papules and pustules on both palms and soles, suggestive of PPP. She received oral corticosteroids in addition to TCZ, with complete regression of symptoms.<\/jats:p>","DOI":"10.1177\/11795441251378521","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T11:17:14Z","timestamp":1758539834000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relapsing Polychondritis With Palmoplantar Pustulosis: A Case Report"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-414X","authenticated-orcid":false,"given":"Lainis","family":"Vasileios","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6717-4617","authenticated-orcid":false,"given":"Katsouli","family":"Olga","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-5328","authenticated-orcid":false,"given":"Vlachoyiannopoulos G","family":"Panayiotis","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-024-00365-z"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6030084"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811302992202"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.026"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197605000-00001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197906000-00009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1763405"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2025.106985"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(86)33695-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91439"},{"key":"e_1_3_3_12_2","first-page":"2181","article-title":"Incidence and mortality of relapsing polychondritis in the UK: a population-based cohort study","volume":"54","author":"Hazra N","year":"2015","unstructured":"Hazra N, Dregan A, Charlton J, Gulliford MC, D\u2019Cruz DP. 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