{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:20:45Z","timestamp":1775107245930,"version":"3.50.1"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med&#65533;Insights&#65533;Arthritis&#65533;Musculoskelet Disord"],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Background:<\/jats:title>\n Osteoarthritis (OA) is a degenerative joint disease characterized by a complex pathophysiology involving inflammatory biomarkers.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n The current study aimed to investigate the correlation between interleukin-6 (IL-6) serum levels and joint space narrowing (JSN) in patients with knee OA.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n A total of 46 patients clinically diagnosed with knee OA were included in this study.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Joint space narrowing was measured using radiographic examinations, whereas blood serum levels of IL-6 were quantified using enzyme-linked immunosorbent assay. Statistical analysis was performed to determine the relationship between IL-6 and JSN.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The average level of IL-6 was 117.61 (67.05) ng\/mL, with JSN measurement of 1.76 (1.31) mm. An inverse correlation found between IL-6 levels and the size of the gap joints in patients with knee OA (\n r<\/jats:italic>\n \u2009=\u2009\u2212.298;\n P<\/jats:italic>\n \u2009=\u2009.044).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n An inverse correlation exists between IL-6 levels and joint impairment in knee OA, suggesting that inflammation plays a crucial role in the progression of the disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/11795441261436818","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:51:46Z","timestamp":1775101906000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin-6 as a Marker of Joint Damage in Osteoarthritis: A Study of Its Pro-inflammatory Impacts"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-7735","authenticated-orcid":false,"given":"Dwitya","family":"Elvira","sequence":"first","affiliation":[{"name":"Allergy and Clinical Immunology Division, Internal Medicine Department, Medical Faculty of Universitas Andalas\/M. Djamil Hospital, Padang, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dela Hangri","family":"Jalmas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Medical Faculty of Universitas Andalas\/M. Djamil Hospital, Padang, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123252"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.10.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24861"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703856114"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-022-00381-y"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05767-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa248"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.add3702"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1536"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-016-4732-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.31661\/jbpe.v0i0.1912-1003"}],"container-title":["Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795441261436818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795441261436818","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795441261436818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:51:49Z","timestamp":1775101909000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795441261436818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":13,"alternative-id":["10.1177\/11795441261436818"],"URL":"https:\/\/doi.org\/10.1177\/11795441261436818","relation":{},"ISSN":["1179-5441","1179-5441"],"issn-type":[{"value":"1179-5441","type":"print"},{"value":"1179-5441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"article-number":"11795441261436818"}}