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Next-generation sequencing continues to expand our understanding of the genetic causes of heritable aortopathies, rapidly clarifying their underlying molecular pathophysiology and suggesting new potential therapeutic targets. This review will summarize the pathogenetic mechanisms and management of heritable genetic aortopathies with attention to specific forms of both syndromic and nonsyndromic disorders, including Marfan syndrome, Loeys-Dietz syndrome, vascular Ehlers-Danlos syndrome, and familial thoracic aortic aneurysm and dissection.<\/jats:p>","DOI":"10.1177\/1179546817709787","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T01:34:13Z","timestamp":1496108053000},"page":"117954681770978","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["The Genetics of Aortopathies in Clinical Cardiology"],"prefix":"10.1177","volume":"11","author":[{"given":"Amit","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali 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