{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:24:09Z","timestamp":1781299449693,"version":"3.54.1"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5T32HL105355-08"],"award-info":[{"award-number":["5T32HL105355-08"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Cardiol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    The purpose of this study was to determine whether the longitudinal progression of decline in left ventricular ejection fraction (LVEF) in Duchenne muscular dystrophy (DMD) patients is moderated by ADRB1 genotype and whether the efficacy of \u00df-blocker therapy is influenced by genotype status. About 147 DMD patients (6-34\u2009years.) were analyzed with a focus on \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    adrenergic receptor (ADRB1) genotype variants. Patients were grouped by ADRB1 genotype resulting in Gly389 patients and Arg389 patients. A generalized additive mixed effects model was used to examine differences in the nonlinear trend of LVEF across patient ages between genotype groups and for \u00df-blocker use. Both genotype groups displayed a progressive decline in LVEF starting around the mean age of ambulation loss (~12\u2009years). However, there was no difference between genotype groups in the progression of decline in LVEF. There was a significant effect of \u00df-blocker use on longitudinal LVEF, wherein patients on \u00df-blockers had systematically lower LVEF when compared to patients not on \u00df-blockers. However, the effect of \u00df-blocker therapy on LVEF was not affected by ADRB1 genotype. The current study did not demonstrate an influence of patient ADRB1 genotype on longitudinal LVEF in our cohort. Despite previous literature suggesting a positive influence of \u00df-blocker use on cardiac function in DMD patients and of an ADRB1 genotypic difference in responsiveness to \u00df-blocker use, we did not observe this in our cohort. Interestingly, our cohort did not demonstrate a positive influence of \u00df-blocker use on LVEF measures.\n                  <\/jats:p>","DOI":"10.1177\/11795468221116838","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T01:08:24Z","timestamp":1661303304000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of \u03b2\n                    <sub>1<\/sub>\n                    Adrenergic Receptor Genotype on Longitudinal Measures of Left Ventricular Ejection Fraction and Responsiveness to \u00df-Blocker Therapy in Patients With Duchenne Muscular Dystrophy"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-2253","authenticated-orcid":false,"given":"Eli F","family":"Kelley","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy J","family":"Cross","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M","family":"McDonald","sequence":"additional","affiliation":[{"name":"University of California Davis Medical Center, Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CINRG","family":"Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Binghamton University\u2014SUNY, Binghamton, NY, USA"},{"name":"Center for Genetic Medicine, Children\u2019s Research Institute, Children\u2019s National Health System, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F","family":"Spurney","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children\u2019s National Heart Institute, Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"bibr1-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.5.472"},{"key":"bibr2-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e318174e4c7"},{"key":"bibr3-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.015151"},{"key":"bibr4-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-009-9156-8"},{"key":"bibr5-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(02)00140-2"},{"key":"bibr6-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30025-5"},{"key":"bibr7-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24163"},{"key":"bibr8-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2448"},{"key":"bibr9-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.018"},{"key":"bibr10-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.01.031"},{"key":"bibr11-11795468221116838","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103186"},{"key":"bibr12-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-007-9113-z"},{"key":"bibr13-11795468221116838","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3259"},{"key":"bibr14-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1177\/1099800409332538"},{"key":"bibr15-11795468221116838","first-page":"715","volume":"84","author":"Pacanowski M","year":"2008","journal-title":"Adolesc Pharmacol"},{"key":"bibr16-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200681200"},{"key":"bibr17-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200202000-00001"},{"key":"bibr18-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.11.008"},{"key":"bibr19-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509937103"},{"key":"bibr20-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.2.187"},{"key":"bibr21-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi115"},{"key":"bibr22-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01006-8"},{"key":"bibr23-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00543-Y"},{"key":"bibr24-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.067"},{"key":"bibr25-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00068-7"},{"key":"bibr26-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00224-8"},{"key":"bibr27-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(02)17734-4"},{"key":"bibr28-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200504000-00006"},{"key":"bibr29-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304013281303"},{"key":"bibr30-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09631"},{"key":"bibr31-11795468221116838","first-page":"733","volume":"99","author":"Farooq U","year":"2014","journal-title":"Med Clin"},{"key":"bibr32-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24370"},{"key":"bibr33-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb00508.x"},{"key":"bibr34-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000001978"},{"key":"bibr35-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20529"},{"key":"bibr36-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.07.025"},{"key":"bibr37-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1201\/9781315370279"},{"key":"bibr38-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2008.00695.x"},{"key":"bibr39-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2007.00646.x"},{"key":"bibr40-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000102042.83024.CA"},{"key":"bibr41-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21748"},{"key":"bibr42-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.09.008"},{"key":"bibr43-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.07.164"},{"key":"bibr44-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.1.65"},{"key":"bibr45-11795468221116838","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000509","volume":"136","author":"Yancy CW","year":"2017","journal-title":"Circulation"},{"key":"bibr46-11795468221116838","first-page":"170","volume":"31","author":"Wollinsky KH","year":"2012","journal-title":"Acta Myol"},{"key":"bibr47-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.213"},{"key":"bibr48-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.118141"},{"key":"bibr49-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.03.002"},{"key":"bibr50-11795468221116838","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.12.008"}],"container-title":["Clinical Medicine Insights: Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795468221116838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795468221116838","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795468221116838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:13:46Z","timestamp":1777389226000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795468221116838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":50,"alternative-id":["10.1177\/11795468221116838"],"URL":"https:\/\/doi.org\/10.1177\/11795468221116838","relation":{},"ISSN":["1179-5468","1179-5468"],"issn-type":[{"value":"1179-5468","type":"print"},{"value":"1179-5468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"11795468221116838"}}