{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:01:35Z","timestamp":1777500095715,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Cardiol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Infiltrative heart disease (InHD) is a group of diseases characterized by the deposition of abnormal substances in the heart tissue, causing diastolic, less often systolic, dysfunction of the ventricle(s). Their classification still does not exist. In 2013, the MOGE(S) classification of cardiomyopathies was published, taking into account, along with the morphological and functional characteristics of the heart, damage to other organs, the presence of genetic mutations, acquired causes (e.g., myocardial inflammation, autoimmune diseases, storage diseases, amyloidosis), etc. By analogy with it we offer the MORAL-STAGE classification for InHD. It includes ten features: morphofunctional characteristics (M), organ damage (O), risk of cardiac death (R), age of clinical presentation, age of disease-specific therapy initiation (A), localization of the infiltrative process (inside or outside the cell, L), information about the functional class heart failure and stage of infiltrative heart disease (S), treatment (T), abnormal rhythm or conduction (A), genetic or familial nature of inheritance (G), etiology of the process (E). This article summarizes the cornerstones of the MORAL-STAGE classification and its clinical relevance. In addition, new issues are discussed that can be considered in future versions of the MORAL-STAGE classification.<\/jats:p>","DOI":"10.1177\/11795468241249075","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T03:00:27Z","timestamp":1727751627000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Classification of Infiltrative Heart Diseases MORAL-STAGE System"],"prefix":"10.1177","volume":"18","author":[{"given":"Elena V","family":"Reznik","sequence":"first","affiliation":[{"name":"Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation, Moscow, Russia"},{"name":"Department of Moscow, \u201cCity Clinical Hospital No 31\u201d of Healthcare, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-4542","authenticated-orcid":false,"given":"Thanh Luan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla N","family":"Semyachkina","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation, Moscow, Russia"},{"name":"Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A","family":"Shkolnikova","sequence":"additional","affiliation":[{"name":"Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation, Moscow, Russia"},{"name":"Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"bibr1-11795468241249075","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.040"},{"key":"bibr2-11795468241249075","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm.2020.02.65"},{"key":"bibr3-11795468241249075","volume-title":"Heart Disease: A Textbook of Cardiovascular Medicine","author":"Braunwald E","year":"2001"},{"key":"bibr4-11795468241249075","unstructured":"Sergeevich MV, Kaluevich KG, Valerievich LP. \u041a\u0430\u0440\u0434\u0438\u043e\u043c\u0438\u043e\u043f\u0430\u0442\u0438\u0438 \u0438 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0438\u0442\u044b. \u0413\u042d\u041e\u0422\u0410\u0420-\u041c\u0435\u0434\u0438\u0430; 2020. 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