{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:01:46Z","timestamp":1777500106597,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Cardiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Iatrogenic atrial septal defect (iASD) resulting from MitraClip procedures may cause volume overload and deterioration of right ventricular (RV) function. The concurrent MitraClip procedure, along with an intervention to close iASD appears to yield a potentially favorable impact on the functioning of the right ventricle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim of the study:<\/jats:title>\n                    <jats:p>The study aims to evaluate the effect of iASD closure with an occluder immediately after the MitraClip procedure on RV function, pulmonary resistance, and right ventricle-pulmonary artery coupling (RV-PAc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study group (ASDc) consisted of consecutive patients who underwent concomitant iASD closure with the Amplatzer occluder (n\u2009=\u200910). The control group (n\u2009=\u20099) comprised patients with iASD left untreated (CT group). RV assessment before MitraClip and during follow-up visits was based on transthoracic echocardiography (TTE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the CT group, fractional area change (FAC) increased from 33.3\u2009\u00b1\u200915.6% to 38.2\u2009\u00b1\u200914.0%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.28, and in the ASDc group, from 38.9\u2009\u00b1\u200911.6% to 40.4\u2009\u00b1\u200913.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.76. In the CT group, tricuspid annular plane systolic excursion (TAPSE) decreased from 19.2\u2009\u00b1\u20094.3\u2009mm to 17.3\u2009\u00b1\u20093.8\u2009mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.47, and in the ASDc group from 19.1\u2009\u00b1\u20096.8\u2009mm to 16.5\u2009\u00b1\u20096.1\u2009mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.04. In the entire group, right ventricular systolic pressure (RVSP) dropped from 52.7\u2009\u00b1\u200916.0\u2009mmHg to 45.1\u2009\u00b1\u20098.1\u2009mmHg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.01. The reduction in RVSP was 11\u2009mmHg in the ASDc group versus 4\u2009mmHg in the CT group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.35). Pulmonary vascular resistance (PVR) itself did not change significantly before and after the procedure. RV-PAc increased respectively by 36% and 9.75% from baseline values in the ASDc and CT groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Closure of the iASD results in a greater reduction in RVSP but also TAPSE. RV-PAc, a parameter unaffected by RV preload, reveals notably improved hemodynamic conditions for RV performance after iASD closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795468251332236","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T07:21:24Z","timestamp":1745047284000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing MitraClip Outcomes: The Case for Routine Iatrogenic ASD Closure"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-8511","authenticated-orcid":false,"given":"Witold","family":"Streb","sequence":"first","affiliation":[{"name":"Department of Cardiology and Electrotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland"},{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Fiszer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland"},{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Mitr\u0119ga","sequence":"additional","affiliation":[{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Podolecki","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland"},{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Kurek","sequence":"additional","affiliation":[{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Lazar","sequence":"additional","affiliation":[{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiktoria","family":"Kowalska","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland"},{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wizner","sequence":"additional","affiliation":[{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-0149","authenticated-orcid":false,"given":"Anita","family":"Stanjek-Cichoracka","sequence":"additional","affiliation":[{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"},{"name":"Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Kalarus","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland"},{"name":"Silesian Centre for Heart Diseases in Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-020-01771-2"},{"issue":"4","key":"e_1_3_2_5_2","article-title":"Risk of stroke with mitral stenosis: the underlying mechanism, treatment, and prevention","volume":"14","author":"Islam H","year":"2022","unstructured":"Islam H, Puttagunta SM, Islam R, et al Risk of stroke with mitral stenosis: the underlying mechanism, treatment, and prevention. 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