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We present the case of a 66-year-old male with a history of stage I prostatic acinar adenocarcinoma who was incidentally found to have a left atrial mass during cancer workup. Multimodal imaging (echocardiography, CMR, PET-CT) initially suggested a benign lesion. The patient underwent surgical excision of the mass, which revealed UPS confirmed by histopathology and immunohistochemistry. Postoperatively, the patient experienced right-sided heart failure, recurrent skin ulcers requiring grafting, and atrial arrhythmia. Despite complications, he stabilized and started chemotherapy and oncologic follow-up. This case highlights the diagnostic pitfalls of cardiac UPS, the necessity for tissue confirmation, and the role of coordinated multidisciplinary care.<\/jats:p>","DOI":"10.1177\/11795468251408695","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:42:20Z","timestamp":1788774140000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Unknown: A Case Report of Undifferentiated Pleomorphic Sarcoma in the Heart"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-7959","authenticated-orcid":false,"given":"Dina Fa","family":"Alwaheidi","sequence":"first","affiliation":[{"name":"Cardiac Surgery Department, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Lateef","family":"Wani","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashfaq","family":"Patel","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.07.087"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000184"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4081\/hi.2012.e4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000106"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2007.48.1.131"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.733"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2334-2"},{"key":"e_1_3_2_9_2","volume-title":"Tumors of the Heart and Great Vessels. 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