{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:42:52Z","timestamp":1783507372437,"version":"3.55.0"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:p>Tumor necrosis factor \u03b1 antagonists are increasingly used to treat inflammatory and autoimmune disorders and are associated with increased risk of active tuberculosis. Diagnosis of active tuberculosis in patients taking tumor necrosis factor \u03b1 antagonists can be challenging owing to increased incidence of extrapulmonary manifestations and false-negative results on current available diagnostic tests. We present a case of a young woman on infliximab for ulcerative colitis who presented with disseminated tuberculosis. As part of a research study, we performed flow cytometric immune profiling, which has previously not been reported in patients with active tuberculosis taking tumor necrosis \u03b1 antagonists. The flow cytometry results were within the positive thresholds for tuberculosis infection. Flow cytometric immune profiling may be a valid diagnostic tool for patients taking tumor necrosis factor \u03b1 antagonists.<\/jats:p>","DOI":"10.1177\/1179547617724776","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T07:53:03Z","timestamp":1503561183000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Flow Cytometric Immune Profiling in Infliximab-Associated Tuberculosis"],"prefix":"10.1177","volume":"10","author":[{"given":"Kelly","family":"Pennington","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto C","family":"Sasieta","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiherme P","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney L","family":"Erskine","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia P","family":"Van Keulen","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Peikert","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Escalante","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA"},{"name":"Mayo Clinic Center for Tuberculosis, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"bibr1-1179547617724776","first-page":"1127","volume":"10","author":"Sichletidis L","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"key":"bibr2-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.8.4591-4599.2002"},{"key":"bibr3-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.93"},{"key":"bibr4-1179547617724776","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4620"},{"key":"bibr5-1179547617724776","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00006"},{"key":"bibr6-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00034-13"},{"key":"bibr7-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2141OC"},{"key":"bibr8-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"bibr9-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77990"},{"key":"bibr10-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017813"},{"key":"bibr11-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12290"},{"key":"bibr12-1179547617724776","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2012.03.008"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179547617724776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1179547617724776","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179547617724776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:13:29Z","timestamp":1777454009000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1179547617724776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":12,"alternative-id":["10.1177\/1179547617724776"],"URL":"https:\/\/doi.org\/10.1177\/1179547617724776","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]},"article-number":"1179547617724776"}}