{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:49:11Z","timestamp":1777693751517,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Study Aims:<\/jats:title>\n                    <jats:p>The prevalence of gallbladder cancer (GBC) varies between different parts of the world. This study is a review of literature and an update of a previously published study conducted in our university and aims to reassess the incidence of GBC over the past 2 decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective study between 2002 and 2016. Data regarding demographics, clinical presentation, risk factors, histopathology, investigations, and treatments were obtained. A diagnosis of GBC established during surgery or primarily detected in the surgical specimen was classified as incidental.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 11 391 cholecystectomies performed, 31 cases (0.27%) of GBC were found. The mean age of patients with GBC was 68\u2009years (43-103\u2009years), 74% were women. The annual incidence of GBC was 0.2\/100 000 (men: 0.1\/100 000; women: 0.3\/100 000). Biliary colic and acute cholecystitis were the main presentations. Diagnosis of GBC was \u201cincidental\u201d in 67% of cases. About 75% of patients with GBC had gallstones, 13% had polyps, and 3% had porcelain gallbladder. Adenocarcinoma was the dominant (87%) histologic type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The GBC rate in our region, similar to others parts of the world, is still low and has not changed over the past 2 decades. This study consolidates the previously published recommendations regarding the high index of suspicion of GBC in elderly with cholelithiasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1179547618771699","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T03:20:00Z","timestamp":1524194400000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Trends of Gallbladder Cancer in Jordan Over 2 Decades: Where Are We?"],"prefix":"10.1177","volume":"11","author":[{"given":"Abdel Rahman","family":"Al Manasra","sequence":"first","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Bani Hani","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitham","family":"Qandeel","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Al Asmar","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alqudah","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Al-Zoubi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Nadig","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Hamouri","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Obeidat","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Al-Muqaimi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"bibr1-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/967472"},{"key":"bibr2-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197601)37:1<141::AID-CNCR2820370121>3.0.CO;2-Y"},{"key":"bibr3-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0302"},{"key":"bibr4-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"bibr5-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1080\/13651820802007464"},{"key":"bibr6-1179547618771699","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1114675"},{"key":"bibr7-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03071.x"},{"key":"bibr8-1179547618771699","unstructured":"Population and housing census report 2015, Jordan. http:\/\/www.dos.gov.jo\/dos_home_a\/main\/population\/census2015\/Persons\/Persons_3.1.pdf. Accessed April 10, 2018."},{"key":"bibr9-1179547618771699","first-page":"303","volume-title":"AJCC Cancer Staging Manual","volume":"2017","author":"American Joint Committee on Cancer","edition":"8"},{"key":"bibr10-1179547618771699","unstructured":"Al-Sayaideh A, Nimri O, Al-Zaghal M, Arqoup K, Halasa W. Cancer incidence in Jordan 2012, Non-Communicable Diseases Directorate, Jordan Cancer Registry, Ministry of Health, Jordan. www.moh.gov.jo. Accessed October 25, 2016."},{"key":"bibr11-1179547618771699","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.8.4461"},{"key":"bibr12-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.07.206"},{"key":"bibr13-1179547618771699","first-page":"239424","volume":"2013","author":"Vijayakumar A","year":"2012","journal-title":"ISRN Radiol"},{"key":"bibr14-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-011-9284-y"},{"key":"bibr15-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1016\/S1479-666X(08)80073-X"},{"key":"bibr16-1179547618771699","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-1-30"},{"key":"bibr17-1179547618771699","first-page":"77","volume":"75","author":"Lowenfels AB","year":"1985","journal-title":"J Natl Cancer Inst"},{"key":"bibr18-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03340170049027"},{"key":"bibr19-1179547618771699","first-page":"99","volume":"6","author":"Hundal R","year":"2014","journal-title":"Clin Epidemiol"},{"key":"bibr20-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21683"},{"key":"bibr21-1179547618771699","first-page":"41","volume":"5","author":"Gupta P","year":"2012","journal-title":"Gastrointest Cancer Res"},{"key":"bibr22-1179547618771699","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.3.1281"},{"key":"bibr23-1179547618771699","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2014.01.003"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179547618771699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1179547618771699","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1179547618771699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:13:34Z","timestamp":1777454014000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1179547618771699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":23,"alternative-id":["10.1177\/1179547618771699"],"URL":"https:\/\/doi.org\/10.1177\/1179547618771699","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"1179547618771699"}}