{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:15:03Z","timestamp":1782958503592,"version":"3.54.5"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>For many years main stay of treatment for sickle cell anaemia was transfusion therapy. But repeated transfusions put the patient at risk of iron overload. Automated red cell exchange is an evolving and newer technique which rapidly removes the sickle cells and has benefit in decreasing sickle cell load and related complications. Red cell exchange is a therapeutic procedure in which the patient\u2019s whole blood is processed centrifugally in cell separator. Patient\u2019s red cells are separated from other blood components and removed and replaced with donor red cells and colloids. We report our first experience of automated red cell exchange in 24-year-old female diagnosed case of sickle cell anaemia presented to us with acute chest syndrome with septic shock. Red cell exchange was planned to tide over the acute sickle cell crisis and provide symptomatic improvement. We also highlight that compound heterozygous thalassaemia could be associated with sickle cell disease which could make the diagnosis difficult. New generation automated Apheresis equipment\u2019s provides better monitoring of the procedure that can be useful in severely ill patients also.<\/jats:p>","DOI":"10.1177\/1179547620970200","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T01:46:13Z","timestamp":1604454373000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of Emergency Automated Red Cell Exchange in Sickle Cell Crisis: A Case Report"],"prefix":"10.1177","volume":"13","author":[{"given":"Anubhav","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"bibr1-1179547620970200","first-page":"8","author":"Hockham C","year":"2018","journal-title":"Sci Rep"},{"key":"bibr2-1179547620970200","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.178582"},{"key":"bibr3-1179547620970200","unstructured":"Gorakshakar AC. 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