{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:51:24Z","timestamp":1777693884492,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM) are frequently accompanied by rapidly progressive-interstitial lung disease (RP-ILD). They are often refractory to intensive immunosuppressive therapy and have poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 73-year-old woman presented with fever, cold symptoms, and skin eruption for a month. She also exhibited muscle weakness on upper extremities slightly. The titer of anti-MDA5 antibody was extremely high, and computed tomography showed ground glass opacity and reticular shadows in the lungs. She was diagnosed as anti-MDA5 antibody-positive classical DM-associated RP-ILD and treated with intensive immunosuppressive therapy. However, the titer of anti-MDA5 antibody did not decrease satisfactorily, and plasma exchange was alternatively initiated. The titer decreased remarkably, and she obtained disease remission. Similarly, a 63-year-old woman presented with stiffness of the neck and hands, fever and cough. She was also diagnosed as anti-MDA5 antibody-positive classical DM-associated RP-ILD, because she had skin eruptions, slight muscle weakness, an elevation in anti-MDA5 antibody, and RP-ILD. She was unresponsive to intensive immunosuppressive therapy, but plasma exchange successfully improved the titer of anti-MDA5 antibody, the symptoms, and the findings of computed tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although anti-MDA5 antibody-positive DM-associated RP-ILD has a high mortality rate, this report suggests the usefulness of plasma exchange to improve the prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795476211036322","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T07:48:02Z","timestamp":1627372082000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Successful Treatment of Anti-MDA5 Antibody-Positive Dermatomyositis-Associated Rapidly Progressive-Interstitial Lung Disease by Plasma Exchange: Two Case Reports"],"prefix":"10.1177","volume":"14","author":[{"given":"Rina","family":"Takahashi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1626-7773","authenticated-orcid":false,"given":"Tadashi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohkichi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuntaro","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mototsugu","family":"Oya","sequence":"additional","affiliation":[{"name":"Apheresis and Dialysis Center, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"},{"name":"Department of Urology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"bibr1-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1002\/art.21023"},{"key":"bibr2-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.03.007"},{"key":"bibr3-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez357"},{"key":"bibr4-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12629"},{"key":"bibr5-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21774"},{"key":"bibr6-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010436"},{"key":"bibr7-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcv068"},{"key":"bibr8-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1080\/24725625.2020.1826641"},{"key":"bibr9-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21824"},{"key":"bibr10-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa123"},{"key":"bibr11-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21833"},{"key":"bibr12-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211468"},{"key":"bibr13-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2020.101016"},{"key":"bibr14-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq149"},{"key":"bibr15-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2017.1318468"},{"key":"bibr16-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key060"},{"key":"bibr17-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1002\/art.41566"},{"key":"bibr18-11795476211036322","doi-asserted-by":"publisher","DOI":"10.1002\/art.37754"}],"container-title":["Clinical 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