{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:52:59Z","timestamp":1777693979465,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Propranolol, a \u03b2-blocker (BB), is one of the drugs that can be misused for suicide. The clinical manifestations of overdose can range from asymptomatic to neurological symptoms such as seizures and loss of consciousness, cardiac shock, and even death. Herein, we describe 2 cases that were referred to our hospital\u2019s emergency department in northern Iran: The first case was a 37-year-old woman who suffered from a decreased level of consciousness, bradycardia, and hypotension after ingesting 4\u2009g of propranolol tablets. In the second case, a 32-year-old woman was admitted with complete cardiac arrest and a suspected history of ingesting 4.8\u2009g of propranolol pills a few hours before admission. Therefore, the time interval between pill intake and treatment initiation seems to be one of the most important factors in prognosis, in addition to the number and dosage of pills ingested.<\/jats:p>","DOI":"10.1177\/11795476221126981","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T02:42:37Z","timestamp":1663987357000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Seizures and Irreversible Cardiogenic Shock Following Propranolol Poisoning: Report of 2 Cases and Literature Review"],"prefix":"10.1177","volume":"15","author":[{"given":"Ali","family":"Sharifpour","sequence":"first","affiliation":[{"name":"Pulmonary and Critical Care Division, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran"},{"name":"Iranian National Registry Center for Lophomoniasis and Toxoplasmosis, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdieh","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakaria","family":"Zakariaei","sequence":"additional","affiliation":[{"name":"Iranian National Registry Center for Lophomoniasis and Toxoplasmosis, Mazandaran University of Medical Sciences, Sari, Iran"},{"name":"Toxicology and Forensic Medicine Division, Orthopedic and Antimicrobial Resistance Research Centers, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Soleymani","sequence":"additional","affiliation":[{"name":"Iranian National Registry Center for Lophomoniasis and Toxoplasmosis, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"bibr1-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03585-7"},{"key":"bibr2-11795476221126981","first-page":"583","volume":"131","author":"Viikki M","year":"2015","journal-title":"Duodecim"},{"key":"bibr3-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115612236"},{"key":"bibr4-11795476221126981","first-page":"336","volume":"24","author":"Stapleton MP.","year":"1997","journal-title":"Tex Heart Inst J"},{"key":"bibr5-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpe.2016.10.001"},{"key":"bibr6-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(03)00372-6"},{"key":"bibr7-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2020.1752918"},{"key":"bibr8-11795476221126981","author":"Khalid MM","year":"2021","journal-title":"StatPearls"},{"key":"bibr9-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.2.162"},{"key":"bibr10-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.05.001"},{"key":"bibr11-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2007.02.001"},{"key":"bibr12-11795476221126981","first-page":"27","volume":"7","author":"Ducret F","year":"1978","journal-title":"Nouv Presse Med"},{"key":"bibr13-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1981.tb09789.x"},{"key":"bibr14-11795476221126981","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.534483"},{"key":"bibr15-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-100100932"},{"key":"bibr16-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(84)90078-0"},{"key":"bibr17-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91803-6"},{"key":"bibr18-11795476221126981","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2011.582471"},{"key":"bibr19-11795476221126981","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/bcpt.13231","volume":"125","author":"Lauterbach M.","year":"2019","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"bibr20-11795476221126981","doi-asserted-by":"publisher","DOI":"10.3109\/15563659609013789"},{"key":"bibr21-11795476221126981","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12763"}],"updated-by":[{"DOI":"10.1177\/11795476221138199","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000}}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476221126981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476221126981","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476221126981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:09Z","timestamp":1777454049000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476221126981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":21,"alternative-id":["10.1177\/11795476221126981"],"URL":"https:\/\/doi.org\/10.1177\/11795476221126981","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"11795476221126981"}}