{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:43:18Z","timestamp":1778622198810,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Multiple myeloma is a hematologic malignancy and a subtype of plasma cell dyscrasias, which accounts for 13% of all hematologic malignancies. It mainly affects older adults and is diagnosed in only 2% of the young population under the age of 40\u2009years. This report presents a 33-year-old man diagnosed with Multiple myeloma with 4 poor prognostic specifications consisting of amplification of the 1q21, Translocation of t(4;14), deletion of the 6q21 and 13q14, along with decreased chromosome count to 44, X,-Y. Even though the combination of 4 poor prognostic cytogenetics in young patients is rare, he responded significantly to the Bortezomib regimen. He was selected as a candidate for bone marrow transplantation. The treatments get interrupted 2\u2009days after the first session of the fifth cycle due to an undesirable COVID-19 infection. After 20\u2009days, the symptoms return, and paraclinical findings show signs of MM relapse.<\/jats:p>","DOI":"10.1177\/11795476231157245","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T12:23:42Z","timestamp":1676723022000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics"],"prefix":"10.1177","volume":"16","author":[{"given":"Effat","family":"Iranijam","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (Hematology division), Ardabil University of Medical Sciences, Ardabil, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somaieh","family":"Matin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (Gastroenterology division), Ardabil University of Medical Sciences, Ardabil, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8293-9139","authenticated-orcid":false,"given":"Mohammad","family":"Negaresh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"bibr1-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011442"},{"key":"bibr2-11795476231157245","doi-asserted-by":"publisher","DOI":"10.4065\/78.1.21"},{"key":"bibr3-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70143-7"},{"key":"bibr4-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4812637"},{"key":"bibr5-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1086\/605664"},{"key":"bibr6-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.1028"},{"key":"bibr7-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"bibr8-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-081018"},{"key":"bibr9-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.174"},{"key":"bibr10-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009910"},{"key":"bibr11-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.2598"},{"key":"bibr12-11795476231157245","first-page":"167","volume":"35","author":"Lawce H","year":"2009","journal-title":"J Assoc Genet Technol"},{"key":"bibr13-11795476231157245","first-page":"217","volume":"32","author":"Li Q","year":"2011","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"bibr14-11795476231157245","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.088211"},{"key":"bibr15-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.3945"},{"key":"bibr16-11795476231157245","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008150"}],"container-title":["Clinical Medicine Insights: Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476231157245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11795476231157245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11795476231157245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:14:15Z","timestamp":1777454055000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11795476231157245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":16,"alternative-id":["10.1177\/11795476231157245"],"URL":"https:\/\/doi.org\/10.1177\/11795476231157245","relation":{},"ISSN":["1179-5476","1179-5476"],"issn-type":[{"value":"1179-5476","type":"print"},{"value":"1179-5476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"11795476231157245"}}