{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:54:02Z","timestamp":1777694042500,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Case Rep"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Blue Rubber Bleb Nevus syndrome (BRBNS) is a rare disorder, that results in congenital cutaneous hemangiomas of the skin and gastrointestinal tract. Although asymptomatic, the nevi present as soft, non-mobile, dark blue, compressible papules. Clinically it presents as iron deficiency anemia due to occult gastrointestinal bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 22-year-old female patient presented with complaints of shortness of breath, fatigue, and palpitation for 2\u2009months. On examination, she had a pale effect and widespread hemangiomas on her lips, hands, and feet. Laboratory results revealed iron deficiency anemia with hemoglobin (Hb) of 2.1\u2009gm\/dl and histopathology results of the hemangioma specimen showed angiokeratomas. Based on clinical manifestations and laboratory results, the patient was diagnosed with a case of BRBNS. The patient was transfused with red cell concentrate her symptoms improved but on the first follow-up visit her Hb again dropped to 8.6\u2009mg\/dl.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A high suspicion of BRBNS diagnosis should be considered if a patient presents with iron deficiency anemia and multiple cutaneous hemangiomas. Further screening should be done to explore internal bleeding and hemangiomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11795476231173503","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T08:15:01Z","timestamp":1684138501000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Blue Rubber Bleb Nevus Syndrome Presenting as Anemia, Hemorrhage, and Hemangiomas: A Rare Case Report"],"prefix":"10.1177","volume":"16","author":[{"given":"Qaisar Ali","family":"Khan","sequence":"first","affiliation":[{"name":"Khyber Teaching Hospital MTI KTH, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Farkouh","sequence":"additional","affiliation":[{"name":"Rush Medical College, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arooba","family":"Khan","sequence":"additional","affiliation":[{"name":"Khyber Teaching Hospital MTI KTH, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahir","family":"Uddin","sequence":"additional","affiliation":[{"name":"Khyber Teaching Hospital MTI KTH, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-3969","authenticated-orcid":false,"given":"Parsa","family":"Abdi","sequence":"additional","affiliation":[{"name":"Memorial University, St. Johns, NL, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"R Anthony","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiza Amatul","family":"Hadi","sequence":"additional","affiliation":[{"name":"Mercer School of Medicine, Macon, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyan","family":"Khan","sequence":"additional","affiliation":[{"name":"Khyber Medical College, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Pervez","sequence":"additional","affiliation":[{"name":"Khyber Teaching Hospital MTI KTH, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"bibr1-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-216963"},{"key":"bibr2-11795476231173503","volume":"99","author":"Hu Z","year":"2020","journal-title":"Medicine"},{"key":"bibr3-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553620"},{"key":"bibr4-11795476231173503","first-page":"59","author":"Carr MM","year":"1996","journal-title":"Can J Surg"},{"key":"bibr5-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.163.111"},{"key":"bibr6-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198607000-00030"},{"key":"bibr7-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580170096013"},{"key":"bibr8-11795476231173503","doi-asserted-by":"publisher","DOI":"10.4174\/jkss.2012.83.5.316"},{"key":"bibr9-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1590\/S0041-87812000000100006"},{"key":"bibr10-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-30172"},{"key":"bibr11-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066139"},{"key":"bibr12-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(92)70339-3"},{"key":"bibr13-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1007\/BF02587162"},{"key":"bibr14-11795476231173503","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i45.17254"},{"key":"bibr15-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2022.01.008"},{"key":"bibr16-11795476231173503","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i16.5406"},{"key":"bibr17-11795476231173503","unstructured":"Macri A, Wilson AM, Shafaat O, et al. Osler-Weber-Rendu Disease. Updated 2022 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Accessed February 26,2023. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482361\/"},{"key":"bibr18-11795476231173503","first-page":"001831","volume":"7","author":"Nunes da Silva I","year":"2020","journal-title":"Eur J Case Rep Intern Med"},{"key":"bibr19-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-207852"},{"key":"bibr20-11795476231173503","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4719-3"},{"key":"bibr21-11795476231173503","unstructured":"Panarelli NC. n.d.). Hereditary Hemorrhagic Telangiectasia. 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